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Descriptor English: Roscovitine
Descriptor Spanish: Roscovitina
Descriptor Portuguese: Roscovitina
Descriptor French: Roscovitine
Entry term(s): (2R)-2-((6-Benzylamino-9-(propan-2-yl)-9H-purin-2-yl)amino)butan-1-ol
2-(1-Ethyl-2-hydroxyethylamino)-6-benzylamino-9-isopropylpurine
CYC 202
CYC-202
CYC202
R roscovitine
R-roscovitine
Seliciclib
Tree number(s): D03.633.100.759.776
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000077546
Scope note: A purine derivative and competitive inhibitor of CYCLIN-DEPENDENT KINASES that has therapeutic potential as an antineoplastic and antiviral agent.
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Antineoplastic Agents
Antiviral Agents
Protein Kinase Inhibitors
Registry Number: 0ES1C2KQ94
Public MeSH Note: 2019; ROSCOVITINE was indexed under PURINES 1997-2018
History Note: 2019 (1997)
DeCS ID: 57671
Unique ID: D000077546
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2019/01/01
Date of Entry: 2018/07/09
Revision Date: 2018/04/09
Roscovitine - Preferred
Concept UI M0273114
Scope note A purine derivative and competitive inhibitor of CYCLIN-DEPENDENT KINASES that has therapeutic potential as an antineoplastic and antiviral agent.
Preferred term Roscovitine
Entry term(s) (2R)-2-((6-Benzylamino-9-(propan-2-yl)-9H-purin-2-yl)amino)butan-1-ol
2-(1-Ethyl-2-hydroxyethylamino)-6-benzylamino-9-isopropylpurine - Related but not broader or narrower
Concept UI M000640881
Preferred term 2-(1-Ethyl-2-hydroxyethylamino)-6-benzylamino-9-isopropylpurine
CYC 202 - Narrower
Concept UI M0462906
Preferred term CYC 202
Entry term(s) CYC-202
CYC202
R-roscovitine - Narrower
Concept UI M0489548
Preferred term R-roscovitine
Entry term(s) R roscovitine
Seliciclib - Narrower
Concept UI M0489549
Preferred term Seliciclib



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