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Descriptor English: Tirapazamine
Descriptor Spanish: Tirapazamina
Descriptor Portuguese: Tirapazamina
Descriptor French: Tirapazamine
Entry term(s): 3-Amino-1,2,4-benzotriazine-1,4-dioxide
NSC 130181
SR 4233
SR-4233
SR4233
Tirazone
WIN 59075
WIN-59075
WIN59075
Tree number(s): D03.383.931.867
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000077704
Scope note: A triazine derivative that introduces breaks into DNA strands in hypoxic cells, sensitizing tumor cells to the cytotoxic activity of other drugs and radiation.
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Antineoplastic Agents
Radiation-Sensitizing Agents
Registry Number: 1UD32YR59G
CAS Type 1 Name: 1,2,4-Benzotriazin-3-amine, 1,4-dioxide
Public MeSH Note: 2019; TIRAPAZAMINE was indexed under TRIAZINES 1986-2018
History Note: 2019 (1986)
DeCS ID: 57722
Unique ID: D000077704
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2019/01/01
Date of Entry: 2018/07/09
Revision Date: 2018/04/09
Tirapazamine - Preferred
Concept UI M0142901
Scope note A triazine derivative that introduces breaks into DNA strands in hypoxic cells, sensitizing tumor cells to the cytotoxic activity of other drugs and radiation.
Preferred term Tirapazamine
Entry term(s) 3-Amino-1,2,4-benzotriazine-1,4-dioxide
NSC 130181 - Narrower
Concept UI M0142896
Preferred term NSC 130181
WIN 59075 - Narrower
Concept UI M0142899
Preferred term WIN 59075
Entry term(s) WIN-59075
WIN59075
Tirazone - Narrower
Concept UI M0446739
Preferred term Tirazone
SR 4233 - Narrower
Concept UI M0142897
Preferred term SR 4233
Entry term(s) SR-4233
SR4233



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