DeCS

Descriptor English:

Tirapazamine

Descriptor Spanish:

Tirapazamina

Spanish from Spain

Descriptor	tirapazamina
Entry term(s)	3-amino-1,2,4-benzotriazina-1,4-dióxido NSC 130181 SR 4233 SR-4233 SR4233 Tirazone WIN 59075 WIN-59075 WIN59075
Scope note:	Derivado triacínico que introduce roturas en las cadenas de ADN en las células hipóxicas, sensibilizando así a las células tumorales a la acción citotóxica de otros fármacos y de la radiación.

Descriptor Portuguese:

Tirapazamina

Descriptor French:

Tirapazamine

Entry term(s):

NSC-130181
SR-4233
WIN-59075

Tree number(s):

D03.383.931.867

RDF Unique Identifier:

https://id.nlm.nih.gov/mesh/D000077704

Scope note:

A triazine derivative that introduces breaks into DNA strands in hypoxic cells, sensitizing tumor cells to the cytotoxic activity of other drugs and radiation.

Allowable Qualifiers:

AA analogues et dérivés
AD administration et posologie
AE effets indésirables
AG agonistes
AI antagonistes et inhibiteurs
AN analyse
BL sang
CF liquide cérébrospinal
CH composition chimique
CL classification
CS synthèse chimique
EC économie
HI histoire
IM immunologie
IP isolement et purification
ME métabolisme
PD pharmacologie
PK pharmacocinétique
PO intoxication
RE effets des radiations
SD ressources et distribution
ST normes
TO toxicité
TU usage thérapeutique
UR urine

Pharm Action:

Antineoplastic Agents
Radiation-Sensitizing Agents

Registry Number:

1UD32YR59G

CAS Type 1 Name:

1,2,4-Benzotriazin-3-amine, 1,4-dioxide

DeCS ID:

57722

Unique ID:

D000077704

Documents indexed in the Virtual Health Library (VHL):

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