| Descriptor English: | 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine | ||||||
| Descriptor Spanish: |
1-(5-Isoquinolinesulfonil)-2-Metilpiperazina
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| Descriptor Portuguese: | 1-(5-Isoquinolinasulfonil)-2-Metilpiperazina | ||||||
| Descriptor French: | 5-(2-Méthyl-pipérazine-1-sulfonyl)isoquinoléine | ||||||
| Entry term(s): |
1-(5-Isoquinolinylsulfonyl)-2-Methylpiperazine H 7 H-7 |
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| Tree number(s): |
D02.886.590.700.545 D03.383.606.527 D03.633.100.531.400 |
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| RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D019307 | ||||||
| Scope note: | A specific protein kinase C inhibitor, which inhibits superoxide release from human neutrophils (PMN) stimulated with phorbol myristate acetate or synthetic diacylglycerol. |
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| Allowable Qualifiers: |
AA analogs & derivatives AD administration & dosage AE adverse effects AG agonists AI antagonists & inhibitors AN analysis BL blood CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis EC economics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UR urine |
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| Pharm Action: |
Enzyme Inhibitors |
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| Registry Number: | 84477-87-2 | ||||||
| CAS Type 1 Name: | Piperazine, 1-(5-isoquinolinylsulfonyl)-2-methyl-, (2S-(1(R*(R*)), 2alpha, 3abeta, 7abeta))- | ||||||
| Previous Indexing: |
Isoquinolines (1985-1996) Piperazines (1985-1996) |
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| Public MeSH Note: | 97; 1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE was indexed under ISOQUINOLINES & PIPERAZINES 1985-96 |
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| Online Note: | use 1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE (NM) to search 1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE 1985-96 |
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| History Note: | 97; was 1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE (NM) 1985-96 |
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| Entry Version: | IQSMP |
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| DeCS ID: | 32992 | ||||||
| Unique ID: | D019307 | ||||||
| Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||||
| Date Established: | 1997/01/01 | ||||||
| Date of Entry: | 1996/06/10 | ||||||
| Revision Date: | 2017/04/10 |
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CHEMICALS AND DRUGS
Organic Chemicals [D02]Organic Chemicals -
CHEMICALS AND DRUGS
Heterocyclic Compounds [D03]Heterocyclic Compounds -
CHEMICALS AND DRUGS
Heterocyclic Compounds [D03]Heterocyclic Compounds
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1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine
- Preferred
| Concept UI |
M0028749 |
| Scope note | A specific protein kinase C inhibitor, which inhibits superoxide release from human neutrophils (PMN) stimulated with phorbol myristate acetate or synthetic diacylglycerol. |
| Preferred term | 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine |
| Entry term(s) |
1-(5-Isoquinolinylsulfonyl)-2-Methylpiperazine H 7 H-7 |
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