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Descriptor English: Debrisoquin
Descriptor Spanish: Debrisoquina
Descriptor Portuguese: Debrisoquina
Descriptor French: Débrisoquine
Entry term(s): Debrisoquine
Tendor
Tree number(s): D03.633.100.531.205
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D003647
Scope note: An adrenergic neuron-blocking drug similar in effects to GUANETHIDINE. It is also noteworthy in being a substrate for a polymorphic cytochrome P-450 enzyme. Persons with certain isoforms of this enzyme are unable to properly metabolize this and many other clinically important drugs. They are commonly referred to as having a debrisoquin 4-hydroxylase polymorphism.
Annotation:
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Antihypertensive Agents
Sympatholytics
Adrenergic Agents
Registry Number: X31CDK040E
CAS Type 1 Name: 2(1H)-Isoquinolinecarboximidamide, 3,4-dihydro-
Previous Indexing: Antihypertensive Agents (1966-1972)
Isoquinolines (1969-1972)
Public MeSH Note: 91; was see under ISOQUINOLINES 1973-90
History Note: 91(73); was see under ISOQUINOLINES 1973-90
DeCS ID: 3665
Unique ID: D003647
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1991/01/01
Date of Entry: 1999/01/01
Revision Date: 2016/05/28
Debrisoquin - Preferred
Concept UI M0005709
Scope note An adrenergic neuron-blocking drug similar in effects to GUANETHIDINE. It is also noteworthy in being a substrate for a polymorphic cytochrome P-450 enzyme. Persons with certain isoforms of this enzyme are unable to properly metabolize this and many other clinically important drugs. They are commonly referred to as having a debrisoquin 4-hydroxylase polymorphism.
Preferred term Debrisoquin
Entry term(s) Debrisoquine
Tendor - Narrower
Concept UI M0005710
Preferred term Tendor



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