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Descriptor English: Glucosylceramidase
Descriptor Spanish: Glucosilceramidasa
Descriptor glucosilceramidasa
Entry term(s) D-glucosil-N-acilesfingosina glucohidrolasa
beta-glucocerebrosidasa
glucocerebrosidasa
Scope note: Glicosidasa que hidroliza una glucosilceramida para dar lugar a ceramida libre más glucosa. En la ENFERMEDAD DE GAUCHER, la deficiencia de esta enzima conduce a concentraciones anormalmente altas de glucosilceramida en el cerebro. EC 3.2.1.45.
Descriptor Portuguese: Glucosilceramidase
Descriptor French: Glucosylceramidase
Entry term(s): Acid beta Glucosidase
Acid beta-Glucosidase
Ceramidase, Glucosyl
Glucocerebrosidase
Glucocerebroside beta Glucosidase
Glucocerebroside beta-Glucosidase
Glucosyl Ceramidase
Glucosyl Hydrolase, Glucosylsphingosine
Glucosylceramide beta Glucosidase
Glucosylceramide beta-Glucosidase
Glucosylsphingosine Glucosyl Hydrolase
Hydrolase, Glucosylsphingosine Glucosyl
beta Glucocerebrosidase
beta-Glucocerebrosidase
beta-Glucosidase, Acid
beta-Glucosidase, Glucocerebroside
beta-Glucosidase, Glucosylceramide
Tree number(s): D08.811.277.450.420.412
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D005962
Scope note: A glycosidase that hydrolyzes a glucosylceramide to yield free ceramide plus glucose. Deficiency of this enzyme leads to abnormally high concentrations of glucosylceramide in the brain in GAUCHER DISEASE. EC 3.2.1.45.
Annotation: /defic: consider also GAUCHER DISEASE
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: EC 3.2.1.45
CAS Type 1 Name: D-Glucosyl-N-acylsphingosine glucosylhydrolase
Previous Indexing: Cerebrosides (1970-1974)
Glucose (1970-1974)
Glycoside Hydrolases (1970-1974)
Public MeSH Note: 91; was see under GLUCOSIDASES 1975-90
History Note: 91(75); was see under GLUCOSIDASES 1975-90
Related: Gaucher Disease MeSH
DeCS ID: 6107
Unique ID: D005962
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1991/01/01
Date of Entry: 1974/11/19
Revision Date: 2013/07/08
Glucosylceramidase - Preferred
Concept UI M0009360
Scope note A glycosidase that hydrolyzes a glucosylceramide to yield free ceramide plus glucose. Deficiency of this enzyme leads to abnormally high concentrations of glucosylceramide in the brain in GAUCHER DISEASE. EC 3.2.1.45.
Preferred term Glucosylceramidase
Entry term(s) Acid beta Glucosidase
Acid beta-Glucosidase
Ceramidase, Glucosyl
Glucocerebrosidase
Glucocerebroside beta Glucosidase
Glucocerebroside beta-Glucosidase
Glucosyl Ceramidase
Glucosyl Hydrolase, Glucosylsphingosine
Glucosylceramide beta Glucosidase
Glucosylceramide beta-Glucosidase
Glucosylsphingosine Glucosyl Hydrolase
Hydrolase, Glucosylsphingosine Glucosyl
beta Glucocerebrosidase
beta-Glucocerebrosidase
beta-Glucosidase, Acid
beta-Glucosidase, Glucocerebroside
beta-Glucosidase, Glucosylceramide



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