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Descriptor English: Lactase-Phlorizin Hydrolase
Descriptor Spanish: Lactasa-Florizina Hidrolasa
Descriptor lactasa-floricina hidrolasa
Entry term(s) floretina-glucosidasa
florizina hidrolasa
glicosilceramidasa
Scope note: Proteína multifuncional que contiene dos dominios enzimáticos. El primer dominio (EC 3.2.1.62) hidroliza la glicosil-N-acilesfingosina dando lugar a un azúcar y N-acilesfingosina. El segundo dominio (EC 3.2.1.108) hidroliza la LACTOSA y se encuentra en la membrana del ribete en cepillo de los enterocitos. La pérdida de actividad de esta enzima en el ser humano origina la INTOLERANCIA A LA LACTOSA.
Descriptor Portuguese: Lactase-Florizina Hidrolase
Descriptor French: Lactase-phlorizin hydrolase
Entry term(s): Ceramidase, Glycosyl
Glycosyl Ceramidase
Glycosylceramidase
Hydrolase, Lactase-Phlorizin
Hydrolase, Phlorizin
Lactase Glycosylceramidase
Lactase Phlorizin Hydrolase
Lactase-Glycosylceramidase
Phloretin Glucosidase
Phloretin-Glucosidase
Phlorizin Hydrolase
Tree number(s): D08.811.277.450.410.100.500.500
D08.811.277.450.420.475
D08.811.641.761
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D010694
Scope note: A multifunctional protein that contains two enzyme domains. The first domain (EC 3.2.1.62) hydrolyzes glycosyl-N-acylsphingosine to a sugar and N-acylsphingosine. The second domain (EC 3.2.1.108) hydrolyzes LACTOSE and is found in the intestinal brush border membrane. Loss of activity for this enzyme in humans results in LACTOSE INTOLERANCE.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: EC 3.2.1.62
Previous Indexing: Glucosidases (1966-1977)
Public MeSH Note: 2014; see GLYCOSYLCERAMIDASE 1992-2013, see PHLORETIN GLUCOSIDASE 1978-1991, see PHLORETIN GLUCOSIDASE 1978-1993
History Note: 2014 (1992)
Related: Lactose Intolerance MeSH
DeCS ID: 30404
Unique ID: D010694
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1991/01/01
Date of Entry: 1977/04/15
Revision Date: 2018/05/21
Lactase-Phlorizin Hydrolase - Preferred
Concept UI M0016614
Scope note A multifunctional protein that contains two enzyme domains. The first domain (EC 3.2.1.62) hydrolyzes glycosyl-N-acylsphingosine to a sugar and N-acylsphingosine. The second domain (EC 3.2.1.108) hydrolyzes LACTOSE and is found in the intestinal brush border membrane. Loss of activity for this enzyme in humans results in LACTOSE INTOLERANCE.
Preferred term Lactase-Phlorizin Hydrolase
Entry term(s) Hydrolase, Lactase-Phlorizin
Lactase Glycosylceramidase
Lactase Phlorizin Hydrolase
Lactase-Glycosylceramidase
Phloretin-Glucosidase - Related but not broader or narrower
Concept UI M000642426
Preferred term Phloretin-Glucosidase
Entry term(s) Phloretin Glucosidase
Phlorizin Hydrolase - Narrower
Concept UI M000638482
Preferred term Phlorizin Hydrolase
Entry term(s) Hydrolase, Phlorizin
Glycosyl Ceramidase - Related but not broader or narrower
Concept UI M000642425
Preferred term Glycosyl Ceramidase
Entry term(s) Ceramidase, Glycosyl
Glycosylceramidase



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