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Descriptor English: Histone Deacetylases
Descriptor Spanish: Histona Desacetilasas
Descriptor histona-desacetilasas
Scope note: Desacetilasas que separan grupos N-acetilo de las cadenas laterales de aminas de los aminoácidos de las HISTONAS. Esta familia de enzimas puede ser dividida al menos en tres subclases definidas estructuralmente. Las desacetilasas de clase I y II utilizan un mecanismo dependiente de zinc. Las sirtuinas son histona desacetilasas que pertenecen a la clase III y son enzimas dependientes de NAD.
Descriptor Portuguese: Histona Desacetilases
Descriptor French: Histone deacetylases
Entry term(s): Class I Histone Deacetylases
Class II Histone Deacetylases
Complexes, Histone Deacetylase
Deacetylase Complexes, Histone
Deacetylase, Histone
Deacetylases, Histone
HDAC Proteins
Histone Deacetylase
Histone Deacetylase Complexes
Tree number(s): D08.811.277.087.520
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D006655
Scope note: Deacetylases that remove N-acetyl groups from amino side chains of the amino acids of HISTONES. The enzyme family can be divided into at least three structurally-defined subclasses. Class I and class II deacetylases utilize a zinc-dependent mechanism. The sirtuin histone deacetylases belong to class III and are NAD-dependent enzymes.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Entry Combination: antagonists & inhibitors:Histone Deacetylase Inhibitors
Registry Number: EC 3.5.1.98
Previous Indexing: Acetic Acids (1971-1974)
Amidohydrolases (1971-1974)
Histones (1971-1974)
Public MeSH Note: 2003; see HISTONE DEACETYLASE 1991-2002; see AMIDOHYDROLASES 1975-1990
History Note: 2003; use AMIDOHYDROLASES 1975-1990
DeCS ID: 6816
Unique ID: D006655
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1991/01/01
Date of Entry: 1974/11/19
Revision Date: 2009/07/06
Histone Deacetylases - Preferred
Concept UI M0010420
Scope note Deacetylases that remove N-acetyl groups from amino side chains of the amino acids of HISTONES. The enzyme family can be divided into at least three structurally-defined subclasses. Class I and class II deacetylases utilize a zinc-dependent mechanism. The sirtuin histone deacetylases belong to class III and are NAD-dependent enzymes.
Preferred term Histone Deacetylases
Entry term(s) Deacetylase, Histone
Deacetylases, Histone
HDAC Proteins
Histone Deacetylase
Histone Deacetylase Complexes - Narrower
Concept UI M0527544
Preferred term Histone Deacetylase Complexes
Entry term(s) Complexes, Histone Deacetylase
Deacetylase Complexes, Histone
Class I Histone Deacetylases - Narrower
Concept UI M0527756
Preferred term Class I Histone Deacetylases
Class II Histone Deacetylases - Narrower
Concept UI M0527757
Preferred term Class II Histone Deacetylases



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