DeCS

Descriptor English:

Insulin

Descriptor Spanish:

Insulina

Spanish from Spain

Descriptor

insulina

Scope note:

Hormona pancreática de 51 aminoácidos que desempeña un papel fundamental en la regulación del metabolismo de la glucosa, directamente mediante la supresión de la producción de glucosa endógena (GLICOGENÓLISIS, GLUCONEOGÉNESIS) e indirectamente inhibiendo la secreción de GLUCAGÓN y la LIPÓLISIS. La insulina original es una proteína globular compuesta por un hexámero coordinado con el zinc. Cada monómero de insulina contiene dos cadenas, A (21 residuos) y B (30 residuos), unidas por dos enlaces disulfuro. La insulina se usa como fármaco para tratar la diabetes mellitus (DIABETES MELLITUS DE TIPO 1).

Descriptor Portuguese:

Insulina

Descriptor French:

Insuline

Entry term(s):

Chaine A de l'insuline
Chaine B de l'insuline
Chaîne A de l'insuline
Chaîne B de l'insuline
Iletin
Insuline ordinaire
Insuline soluble
Novolin

Tree number(s):

D06.472.699.587.200.500.625
D12.644.548.586.200.500.625

RDF Unique Identifier:

https://id.nlm.nih.gov/mesh/D007328

Scope note:

A 51-amino acid pancreatic hormone that plays a major role in the regulation of glucose metabolism, directly by suppressing endogenous glucose production (GLYCOGENOLYSIS; GLUCONEOGENESIS) and indirectly by suppressing GLUCAGON secretion and LIPOLYSIS. Native insulin is a globular protein comprised of a zinc-coordinated hexamer. Each insulin monomer containing two chains, A (21 residues) and B (30 residues), linked by two disulfide bonds. Insulin is used as a drug to control insulin-dependent diabetes mellitus (DIABETES MELLITUS, TYPE 1).

Annotation:

/blood: consider also HYPERINSULINEMIA (excessively high blood insulin levels) but do not confuse with HYPERINSULINISM (excessive secretion of insulin by pancreas); /immunology: consider also INSULIN ANTIBODIES; precursor = PROINSULIN; INSULIN INFUSION SYSTEMS is available

Allowable Qualifiers:

AA analogues et dérivés
AD administration et posologie
AE effets indésirables
AG agonistes
AN analyse
BI biosynthèse
BL sang
CF liquide cérébrospinal
CH composition chimique
CL classification
CS synthèse chimique
DF déficit
EC économie
GE génétique
HI histoire
IM immunologie
IP isolement et purification
ME métabolisme
PD pharmacologie
PH physiologie
PK pharmacocinétique
PO intoxication
RE effets des radiations
SD ressources et distribution
ST normes
TO toxicité
TU usage thérapeutique
UR urine

Entry Combination:

antagonists & inhibitors:Insulin Antagonists

Pharm Action:

Hypoglycemic Agents