Descriptor English: Insulin
Descriptor Spanish: Insulina
Descriptor Portuguese: Insulina
Descriptor French: Insuline
Entry term(s): Chaine A de l'insuline
Chaine B de l'insuline
Chaîne A de l'insuline
Chaîne B de l'insuline
Insuline ordinaire
Insuline soluble
Tree number(s): D06.472.699.587.200.500.625
RDF Unique Identifier:
Scope note: A 51-amino acid pancreatic hormone that plays a major role in the regulation of glucose metabolism, directly by suppressing endogenous glucose production (GLYCOGENOLYSIS; GLUCONEOGENESIS) and indirectly by suppressing GLUCAGON secretion and LIPOLYSIS. Native insulin is a globular protein comprised of a zinc-coordinated hexamer. Each insulin monomer containing two chains, A (21 residues) and B (30 residues), linked by two disulfide bonds. Insulin is used as a drug to control insulin-dependent diabetes mellitus (DIABETES MELLITUS, TYPE 1).
Annotation: /blood: consider also HYPERINSULINEMIA (excessively high blood insulin levels) but do not confuse with HYPERINSULINISM (excessive secretion of insulin by pancreas); /immunology: consider also INSULIN ANTIBODIES; precursor = PROINSULIN; INSULIN INFUSION SYSTEMS is available
Allowable Qualifiers: AA analogues et dérivés
AD administration et posologie
AE effets indésirables
AG agonistes
AN analyse
BI biosynthèse
BL sang
CF liquide cérébrospinal
CH composition chimique
CL classification
CS synthèse chimique
DF déficit
EC économie
GE génétique
HI histoire
IM immunologie
IP isolement et purification
ME métabolisme
PD pharmacologie
PH physiologie
PK pharmacocinétique
PO intoxication
RE effets des radiations
SD ressources et distribution
ST normes
TO toxicité
TU usage thérapeutique
UR urine
Entry Combination: antagonists & inhibitors:Insulin Antagonists
Related: Activité de type insulinique non suppressible MeSH
Hyperinsulinisme MeSH
Proinsuline MeSH
Récepteur à l'insuline MeSH
DeCS ID: 7500
Unique ID: D007328
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1966/01/01
Date of Entry: 1999/01/01
Revision Date: 2011/06/24
Insuline - Preferred
Concept UI M0011417
Preferred term Insuline
Entry term(s) Insuline ordinaire
Insuline soluble
Chaine A de l'insuline - Narrower
Concept UI M0011418
Preferred term Chaine A de l'insuline
Entry term(s) Chaîne A de l'insuline
Novolin - Narrower
Concept UI M0011420
Preferred term Novolin
Iletin - Narrower
Concept UI M0011416
Preferred term Iletin
Chaine B de l'insuline - Narrower
Concept UI M0557300
Preferred term Chaine B de l'insuline
Entry term(s) Chaîne B de l'insuline

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