DeCS

Descriptor English:

Receptor, Insulin

Descriptor Spanish:

Receptor de Insulina

Spanish from Spain

Descriptor	receptor de insulina
Entry term(s)	proteína tirosina cinasa del receptor de insulina proteína tirosina cinasa receptora de insulina receptor insulínico subunidad alfa del receptor de insulina subunidad beta del receptor de insulina
Scope note:	Receptor de la superficie celular para la INSULINA. Consiste en un tetrámetro de dos subunidades alfa y dos beta, que derivan de la escisión de una única proteína precursora. El receptor contiene un dominio intrínseco tirosina cinasa localizado en la subunidad beta. La activación del receptor por la INSULINA da lugar a numerosos cambios metabólicos, incluído el incremento de la captación de GLUCOSA por el HÍGADO, MÚSCULO y TEJIDO ADIPOSO.

Descriptor Portuguese:

Receptor de Insulina

Descriptor French:

Récepteur à l'insuline

Entry term(s):

Insulin Receptor
Insulin Receptor Protein Tyrosine Kinase
Insulin Receptor Protein-Tyrosine Kinase
Insulin Receptor alpha Chain
Insulin Receptor alpha Subunit
Insulin Receptor beta Chain
Insulin Receptor beta Subunit
Insulin Receptors
Insulin-Dependent Tyrosine Protein Kinase
Receptors, Insulin

Tree number(s):

D08.811.913.696.620.682.725.400.200
D12.776.476.568.400.200
D12.776.543.750.630.484
D12.776.543.750.750.580.300

RDF Unique Identifier:

https://id.nlm.nih.gov/mesh/D011972

Scope note:

A cell surface receptor for INSULIN. It comprises a tetramer of two alpha and two beta subunits which are derived from cleavage of a single precursor protein. The receptor contains an intrinsic TYROSINE KINASE domain that is located within the beta subunit. Activation of the receptor by INSULIN results in numerous metabolic changes including increased uptake of GLUCOSE into the liver, muscle, and ADIPOSE TISSUE.

Allowable Qualifiers:

AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine

Registry Number:

EC 2.7.10.1

Previous Indexing:

Insulin (1966-1976)
Receptors, Drug (1968-1976)
Receptors, Endogenous Substances (1973-1976)

Public MeSH Note:

2000; for INSULIN RECEPTOR PROTEIN-TYROSINE KINASE see INSULIN RECEPTOR PROTEIN-TYROSINE KINASE 1994-1999; INSULIN-DEPENDENT PROTEIN TYROSINE KINASE was indexed under PROTEIN-TYROSINE KINASE 1986-1993 & PROTEIN KINASES 1983-1985

Concept UI	M0018605
Scope note	A cell surface receptor for INSULIN. It comprises a tetramer of two alpha and two beta subunits which are derived from cleavage of a single precursor protein. The receptor contains an intrinsic TYROSINE KINASE domain that is located within the beta subunit. Activation of the receptor by INSULIN results in numerous metabolic changes including increased uptake of GLUCOSE into the liver, muscle, and ADIPOSE TISSUE.
Preferred term	Receptor, Insulin
Entry term(s)	Insulin Receptor Insulin Receptor Protein Tyrosine Kinase Insulin Receptor Protein-Tyrosine Kinase Insulin Receptors Insulin-Dependent Tyrosine Protein Kinase Receptors, Insulin

Concept UI	M0331648
Preferred term	Insulin Receptor beta Subunit
Entry term(s)	Insulin Receptor beta Chain

Concept UI	M0331647
Preferred term	Insulin Receptor alpha Subunit
Entry term(s)	Insulin Receptor alpha Chain

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