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Descriptor English: Leucyl Aminopeptidase
Descriptor Spanish: Leucil Aminopeptidasa
Descriptor leucil aminopeptidasa
Entry term(s) citosol aminopeptidasa
leucil beta-naftilamidasa
leucina aminopeptidasa
Scope note: Enzima de la clase de las hidrolasas que contiene zinc y cataliza la separación del aminoácido N-terminal de la mayoría de los L-péptidos, particularmente aquellos con residuos de leucina N-terminal, pero los que contienen residuos N-terminales de lisina o arginina. Esto tiene lugar en el citosol celular y existe elevada actividad en el duodeno, hígado y riñón. EC 3.4.11.1.
Descriptor Portuguese: Leucil Aminopeptidase
Descriptor French: Leucyl Aminopeptidase
Entry term(s): Aminopeptidase, Cytosol
Aminopeptidase, Leucine
Aminopeptidase, Leucyl
Aminopeptidase, Methoxyleucine
Aminopeptidase, Zinc-Manganese-Leucine
Cytosol Aminopeptidase
L-Leucylnaphthylamidase
Leucine Aminopeptidase
Methoxyleucine Aminopeptidase
Peptidase S
Zinc Manganese Leucine Aminopeptidase
Zinc-Manganese-Leucine Aminopeptidase
Tree number(s): D08.811.277.656.350.100.511
D08.811.277.656.350.555.700
D08.811.277.656.675.555.700
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D007931
Scope note: A zinc containing enzyme of the hydrolase class that catalyzes the removal of the N-terminal amino acid from most L-peptides, particularly those with N-terminal leucine residues but not those with N-terminal lysine or arginine residues. This occurs in tissue cell cytosol, with high activity in the duodenum, liver, and kidney. The activity of this enzyme is commonly assayed using a leucine arylamide chromogenic substrate such as leucyl beta-naphthylamide.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: EC 3.4.11.1
Public MeSH Note: 1999; see LEUCINE AMINOPEPTIDASE 1965-1998; PEPTIDASE S was indexed under AMINOPEPTIDASES 1979-1998; for LEUCYL-BETA-NAPTHYLAMIDASE see LEUCYL-BETA-NAPTHYLAMIDASE 1991-2009
History Note: 1999(1965)
DeCS ID: 8109
Unique ID: D007931
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1965/01/01
Date of Entry: 1999/01/01
Revision Date: 2016/06/28
Leucyl Aminopeptidase - Preferred
Concept UI M0012373
Scope note A zinc containing enzyme of the hydrolase class that catalyzes the removal of the N-terminal amino acid from most L-peptides, particularly those with N-terminal leucine residues but not those with N-terminal lysine or arginine residues. This occurs in tissue cell cytosol, with high activity in the duodenum, liver, and kidney. The activity of this enzyme is commonly assayed using a leucine arylamide chromogenic substrate such as leucyl beta-naphthylamide.
Preferred term Leucyl Aminopeptidase
Entry term(s) Aminopeptidase, Cytosol
Aminopeptidase, Leucine
Aminopeptidase, Leucyl
Aminopeptidase, Zinc-Manganese-Leucine
Cytosol Aminopeptidase
L-Leucylnaphthylamidase
Leucine Aminopeptidase
Peptidase S
Zinc Manganese Leucine Aminopeptidase
Zinc-Manganese-Leucine Aminopeptidase
Methoxyleucine Aminopeptidase - Narrower
Concept UI M0012374
Preferred term Methoxyleucine Aminopeptidase
Entry term(s) Aminopeptidase, Methoxyleucine



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