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Descriptor English: Pregnenolone Carbonitrile
Descriptor Spanish: Carbonitrilo de Pregnenolona
Descriptor carbonitrilo de pregnenolona
Scope note: Esteroide catatóxico e inductor enzimático microsómico que tiene efectos significativos sobre la inducción del citocromo P450. Se ha demostrado su potencial capacidad protectora contra el daño hepático inducido por paracetamol.
Descriptor Portuguese: Carbonitrila de Pregnenolona
Descriptor French: Prégnénolone carbonitrile
Entry term(s): 16 alpha-Carbonitrile, Pregnenolone
Carbonitrile, Pregnenolone
PCN
Pregnenolone 16 alpha Carbonitrile
Pregnenolone 16 alpha-Carbonitrile
Pregnenolone Carbonitrile, (3 beta)-Isomer
Pregnenolone Carbonitrile, (3 beta,16 beta)-Isomer
Tree number(s): D02.626.745
D04.210.500.745.745.725.703
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D011285
Scope note: A catatoxic steroid and microsomal enzyme inducer having significant effects on the induction of cytochrome P450. It has also demonstrated the potential for protective capability against acetaminophen-induced liver damage.
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Registry Number: 1434-54-4
CAS Type 1 Name: Pregn-5-ene-16-carbonitrile, 3-hydroxy-20-oxo-, (3beta,16alpha)-
Public MeSH Note: 74
History Note: 74
DeCS ID: 11721
Unique ID: D011285
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1974/01/01
Date of Entry: 1999/01/01
Revision Date: 2016/05/31
Pregnenolone Carbonitrile - Preferred
Concept UI M0017517
Scope note A catatoxic steroid and microsomal enzyme inducer having significant effects on the induction of cytochrome P450. It has also demonstrated the potential for protective capability against acetaminophen-induced liver damage.
Preferred term Pregnenolone Carbonitrile
Entry term(s) 16 alpha-Carbonitrile, Pregnenolone
Carbonitrile, Pregnenolone
PCN
Pregnenolone 16 alpha Carbonitrile
Pregnenolone 16 alpha-Carbonitrile
Pregnenolone Carbonitrile, (3 beta,16 beta)-Isomer - Related but not broader or narrower
Concept UI M0329752
Preferred term Pregnenolone Carbonitrile, (3 beta,16 beta)-Isomer
Pregnenolone Carbonitrile, (3 beta)-Isomer - Related but not broader or narrower
Concept UI M0329753
Preferred term Pregnenolone Carbonitrile, (3 beta)-Isomer



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