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Descriptor English: Letrozole
Descriptor Spanish: Letrozol
Descriptor letrozol
Entry term(s) 4,4'-(1H-1,2,4-triazol-1-il-metilen)-bis(benzonitrilo)
CGS 20267
CGS-20267
CGS20267
Femara
Scope note: Derivado de triazol y benzonitrilo que es un inhibidor no esteroideo selectivo de la aromatasa, similar al ANASTROZOL. Se usa en el tratamiento del cáncer de mama localmente avanzado o metastásico en mujeres posmenopáusicas.
Descriptor Portuguese: Letrozol
Descriptor French: Létrozole
Entry term(s): 4,4'-(1H-1,2,4-triazol-1-yl-methylene)-bis(benzonitrile)
CGS 20267
CGS-20267
CGS20267
Femara
Fémara
Tree number(s): D02.626.300
D03.383.129.799.638
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000077289
Scope note: A triazole and benzonitrile derivative that is a selective non-steroidal aromatase inhibitor, similar to ANASTROZOLE. It is used in the treatment of metastatic or locally advanced breast cancer in postmenopausal women.
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Antineoplastic Agents
Aromatase Inhibitors
Registry Number: 7LKK855W8I
CAS Type 1 Name: Benzonitrile, 4,4'-(1H-1,2,4-triazol-1-ylmethylene)bis-
Public MeSH Note: 2019; LETROZOLE was indexed under NITRILES and TRIAZOLES 1991-2018
History Note: 2019 (1991)
DeCS ID: 57590
Unique ID: D000077289
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2019/01/01
Date of Entry: 2018/07/09
Revision Date: 2018/02/27
Letrozole - Preferred
Concept UI M000640349
Scope note A triazole and benzonitrile derivative that is a selective non-steroidal aromatase inhibitor, similar to ANASTROZOLE. It is used in the treatment of metastatic or locally advanced breast cancer in postmenopausal women.
Preferred term Letrozole
Entry term(s) 4,4'-(1H-1,2,4-triazol-1-yl-methylene)-bis(benzonitrile)
CGS 20267 - Narrower
Concept UI M0184833
Preferred term CGS 20267
Entry term(s) CGS-20267
CGS20267
Femara - Narrower
Concept UI M0399882
Preferred term Femara
Entry term(s) Fémara



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