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Descriptor English: Renin-Angiotensin System
Descriptor Spanish: Sistema Renina-Angiotensina
Descriptor sistema renina-angiotensina
Entry term(s) sistema renina-angiotensina-aldosterona
Scope note: Sistema regulador de la PRESIÓN ARTERIAL en el que interactúan componentes tales como: RENINA, ANGIOTENSINA, ENZIMA CONVERTIDORA DE ANGIOTENSINA, ANGIOTENSINA I, ANGIOTENSINA II, y angiotensinasa. La renina, una enzima producida en el riñón, actúa sobre el angiotensinógeno, una globulina alfa-2 producida en el hígado, para formar ANGIOTENSINA I. La enzima convertidora de angiotensina, contenida en el pulmón, actúa sobre la angiotensina I plasmática, convirtiéndola en ANGIOTENSINA II, que es un agente vasoconstrictor extremadamente potente. La angiotensina II causa contracción del MUSCULO LISO VASCULAR arteriolar y renal, lo que provoca una retención de sal y agua por parte del RIÑÓN y un incremento de la presión arterial. Además, la angiotensina II estimula la liberación de ALDOSTERONA en la CORTEZA SUPRARRENAL que, a su vez, incrementa la retención de sal y agua en el riñón. La enzima convertidora de angiotensina inactiva a la BRADIQUININA, un poderoso vasodilatador y componente del SISTEMA CALICREÍNA-CININA.
Descriptor Portuguese: Sistema Renina-Angiotensina
Descriptor French: Système rénine-angiotensine
Entry term(s): Renin Angiotensin Aldosterone System
Renin Angiotensin System
Renin-Angiotensin-Aldosterone System
System, Renin-Angiotensin
System, Renin-Angiotensin-Aldosterone
Tree number(s): G03.820
G09.330.380.813
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D012084
Scope note: A BLOOD PRESSURE regulating system of interacting components that include RENIN; ANGIOTENSINOGEN; ANGIOTENSIN CONVERTING ENZYME; ANGIOTENSIN I; ANGIOTENSIN II; and angiotensinase. Renin, an enzyme produced in the kidney, acts on angiotensinogen, an alpha-2 globulin produced by the liver, forming ANGIOTENSIN I. Angiotensin-converting enzyme, contained in the lung, acts on angiotensin I in the plasma converting it to ANGIOTENSIN II, an extremely powerful vasoconstrictor. Angiotensin II causes contraction of the arteriolar and renal VASCULAR SMOOTH MUSCLE, leading to retention of salt and water in the KIDNEY and increased arterial blood pressure. In addition, angiotensin II stimulates the release of ALDOSTERONE from the ADRENAL CORTEX, which in turn also increases salt and water retention in the kidney. Angiotensin-converting enzyme also breaks down BRADYKININ, a powerful vasodilator and component of the KALLIKREIN-KININ SYSTEM.
Annotation: note entry term but do not index under ALDOSTERONE unless particularly discussed
Allowable Qualifiers: DE drug effects
GE genetics
IM immunology
PH physiology
RE radiation effects
Previous Indexing: Angiotensin II (1966-1981)
Renin (1966-1981)
Public MeSH Note: 82
History Note: 82
Entry Version: RA SYSTEM
Related: Angiotensin-Converting Enzyme Inhibitors MeSH
Kallikrein-Kinin System MeSH
DeCS ID: 12506
Unique ID: D012084
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1982/01/01
Date of Entry: 1981/05/19
Revision Date: 2016/07/01
Renin-Angiotensin System - Preferred
Concept UI M0018777
Scope note A BLOOD PRESSURE regulating system of interacting components that include RENIN; ANGIOTENSINOGEN; ANGIOTENSIN CONVERTING ENZYME; ANGIOTENSIN I; ANGIOTENSIN II; and angiotensinase. Renin, an enzyme produced in the kidney, acts on angiotensinogen, an alpha-2 globulin produced by the liver, forming ANGIOTENSIN I. Angiotensin-converting enzyme, contained in the lung, acts on angiotensin I in the plasma converting it to ANGIOTENSIN II, an extremely powerful vasoconstrictor. Angiotensin II causes contraction of the arteriolar and renal VASCULAR SMOOTH MUSCLE, leading to retention of salt and water in the KIDNEY and increased arterial blood pressure. In addition, angiotensin II stimulates the release of ALDOSTERONE from the ADRENAL CORTEX, which in turn also increases salt and water retention in the kidney. Angiotensin-converting enzyme also breaks down BRADYKININ, a powerful vasodilator and component of the KALLIKREIN-KININ SYSTEM.
Preferred term Renin-Angiotensin System
Entry term(s) Renin Angiotensin System
System, Renin-Angiotensin
Renin-Angiotensin-Aldosterone System - Broader
Concept UI M0018778
Preferred term Renin-Angiotensin-Aldosterone System
Entry term(s) Renin Angiotensin Aldosterone System
System, Renin-Angiotensin-Aldosterone



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