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Descriptor English: Tetrahydrofolate Dehydrogenase
Descriptor Spanish: Tetrahidrofolato Deshidrogenasa
Descriptor tetrahidrofolato deshidrogenasa
Entry term(s) dihidrofolato deshidrogenasa
dihidrofolato reductasa
ácido fólico reductasa
Scope note: Enzima perteneciente a la clase oxidorreductasas que cataliza la reacción del 7.8-dihidrofolato y NADPH dando lugar a 5,6,7,8-tetrahidrofolato y NADPH+; como resultado de la reacción se forma folato reducido para el metabolismo de los aminoácidos, la síntesis del anillo de purina y la formación de monofosfato de desoxitimidina. El metotrexato y otros compuestos antagonistas del ácido fólico, que se utilizan como fármacos quimioterapéuticos, inhiben esta enzima. (Dorland, 27th ed) EC 1.5.1.3.
Descriptor Portuguese: Tetra-Hidrofolato Desidrogenase
Descriptor French: Dihydrofolate reductase
Entry term(s): Acid Reductase, Folic
Dehydrogenase, Dihydrofolate
Dehydrogenase, Tetrahydrofolate
Dihydrofolate Dehydrogenase
Dihydrofolate Reductase
Folic Acid Reductase
Reductase, Dihydrofolate
Reductase, Folic Acid
Tree number(s): D08.811.682.662.825
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D013762
Scope note: An enzyme of the oxidoreductase class that catalyzes the reaction 7,8-dihyrofolate and NADPH to yield 5,6,7,8-tetrahydrofolate and NADPH+, producing reduced folate for amino acid metabolism, purine ring synthesis, and the formation of deoxythymidine monophosphate. Methotrexate and other folic acid antagonists used as chemotherapeutic drugs act by inhibiting this enzyme. (Dorland, 27th ed) EC 1.5.1.3.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Entry Combination: antagonists & inhibitors:Folic Acid Antagonists
Registry Number: EC 1.5.1.3
CAS Type 1 Name: 5,6,7,8-Tetrahydrofolate:NADP+ oxidoreductase
Public MeSH Note: 66; DIHYDROFOLATE DEHYDROGENASE was heading 1966-88
Online Note: use TETRAHYDROFOLATE DEHYDROGENASE to search DIHYDROFOLATE DEHYDROGENASE 1966-88
History Note: 66; DIHYDROFOLATE DEHYDROGENASE was heading 1966-88
DeCS ID: 14141
Unique ID: D013762
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1966/01/01
Date of Entry: 1999/01/01
Revision Date: 2005/06/30
Tetrahydrofolate Dehydrogenase - Preferred
Concept UI M0021232
Scope note An enzyme of the oxidoreductase class that catalyzes the reaction 7,8-dihyrofolate and NADPH to yield 5,6,7,8-tetrahydrofolate and NADPH+, producing reduced folate for amino acid metabolism, purine ring synthesis, and the formation of deoxythymidine monophosphate. Methotrexate and other folic acid antagonists used as chemotherapeutic drugs act by inhibiting this enzyme. (Dorland, 27th ed) EC 1.5.1.3.
Preferred term Tetrahydrofolate Dehydrogenase
Entry term(s) Acid Reductase, Folic
Dehydrogenase, Dihydrofolate
Dehydrogenase, Tetrahydrofolate
Dihydrofolate Dehydrogenase
Dihydrofolate Reductase
Folic Acid Reductase
Reductase, Dihydrofolate
Reductase, Folic Acid



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