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Descriptor English: Methylenetetrahydrofolate Dehydrogenase (NADP)
Descriptor Spanish: Metilenotetrahidrofolato Deshidrogenasa (NADP)
Descriptor metilenotetrahidrofolato deshidrogenasa (NADP)
Entry term(s) metilenotetrahidrofolato deshidrogenasa (NADP+)
Scope note: Oxidoreductasa dependiente del NADP que cataliza la conversión del 5,10-metilenotetrahidrofolato a 5,10-meteniltetrahidrofolato. En eucariotas superiores existe una enzima trifuncional con actividad adicional de METENILTETRAHIDROFOLATO CICLOHIDROLASA y FORMATO-TETRAHIDROFOLATO LIGASA. La enzima tiene un importante papel en la síntesis del 5-metiltetrahidrofolato, donante de metilo para la remetilación de la HOMOCISTEINA dependiente de VITAMINA B 12 a METIONINA, vía METIONINA SINTETASA.
Descriptor Portuguese: Metilenotetra-Hidrofolato Desidrogenase (NADP)
Descriptor French: Methylenetetrahydrofolate Dehydrogenase (NADP)
Entry term(s): Dehydrogenase, Methylenetetrahydrofolate
Methylenetetrahydrofolate Dehydrogenase
Methylenetetrahydrofolate Dehydrogenase (NADP+)
Tree number(s): D08.811.682.662.253
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D008754
Scope note: An NADP-dependent oxidoreductase that catalyses the conversion of 5,10-methyleneterahydrofolate to 5,10-methenyl-tetrahydrofolate. In higher eukaryotes a trifunctional enzyme exists with additional METHENYLTETRAHYDROFOLATE CYCLOHYDROLASE and FORMATE-TETRAHYDROFOLATE LIGASE activity. The enzyme plays an important role in the synthesis of 5-methyltetrahydrofolate, the methyl donor for the VITAMIN B12-dependent remethylation of HOMOCYSTEINE to METHIONINE via METHIONINE SYNTHETASE.
Annotation: do not confuse with METHYLENETETRAHYDROFOLATE DEHYDROGENASE (NAD+)
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: EC 1.5.1.5
CAS Type 1 Name: 5,10-Methylenetetrahydrofolate:NADP+ oxidoreductase
Previous Indexing: Oxidoreductases (1973-1974)
Tetrahydrofolates (1973-1974)
Public MeSH Note: 2004; see METHYLENETETRAHYDROFOLATE DEHYDROGENASE 1991-2003; see OXIDOREDUCTASES 1975-1990
History Note: 2004(1975);
Related: Formate-Tetrahydrofolate Ligase MeSH
Methenyltetrahydrofolate Cyclohydrolase MeSH
DeCS ID: 8940
Unique ID: D008754
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1991/01/01
Date of Entry: 1974/11/19
Revision Date: 2006/07/05
Methylenetetrahydrofolate Dehydrogenase (NADP) - Preferred
Concept UI M0013632
Scope note An NADP-dependent oxidoreductase that catalyses the conversion of 5,10-methyleneterahydrofolate to 5,10-methenyl-tetrahydrofolate. In higher eukaryotes a trifunctional enzyme exists with additional METHENYLTETRAHYDROFOLATE CYCLOHYDROLASE and FORMATE-TETRAHYDROFOLATE LIGASE activity. The enzyme plays an important role in the synthesis of 5-methyltetrahydrofolate, the methyl donor for the VITAMIN B12-dependent remethylation of HOMOCYSTEINE to METHIONINE via METHIONINE SYNTHETASE.
Preferred term Methylenetetrahydrofolate Dehydrogenase (NADP)
Entry term(s) Dehydrogenase, Methylenetetrahydrofolate
Methylenetetrahydrofolate Dehydrogenase
Methylenetetrahydrofolate Dehydrogenase (NADP+)



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