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Descriptor English: DNA Damage
Descriptor Spanish: Daño del ADN
Descriptor daño del ADN
Entry term(s) daño del DNA
estrés genotóxico
lesiones del ADN
Scope note: Lesiones en el ADN que provocan desviaciones de su estructura intacta normal y que, de no ser reparadas, pueden derivar en una MUTACIÓN o un bloqueo en la REPLICACIÓN DEL ADN. Estas desviaciones pueden deberse a la acción de agentes físicos o químicos y producirse por circunstancias sobrevenidas naturales o no. Estos cambios incluyen una introducción de bases inapropiadas durante la replicación, ya sea por desaminación u otras modificaciones; pérdida de una base en la cadena de ADN; roturas en una cadena; roturas en las dos cadenas; y enlaces cruzados intracadenas (DÍMEROS DE PIRIMIDINA) o intercadenas. El daño con frecuencia puede ser reparado (REPARACIÓN DEL ADN). Si el daño es grande, puede inducir APOPTOSIS.
Descriptor Portuguese: Dano ao DNA
Descriptor French: Altération de l'ADN
Entry term(s): DNA Damages
DNA Injuries
DNA Injury
Damage, DNA
Damages, DNA
Genotoxic Stress
Genotoxic Stresses
Injuries, DNA
Injury, DNA
Stress, Genotoxic
Stresses, Genotoxic
Tree number(s): G05.200
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D004249
Scope note: Injuries to DNA that introduce deviations from its normal, intact structure and which may, if left unrepaired, result in a MUTATION or a block of DNA REPLICATION. These deviations may be caused by physical or chemical agents and occur by natural or unnatural, introduced circumstances. They include the introduction of illegitimate bases during replication or by deamination or other modification of bases; the loss of a base from the DNA backbone leaving an abasic site; single-strand breaks; double strand breaks; and intrastrand (PYRIMIDINE DIMERS) or interstrand crosslinking. Damage can often be repaired (DNA REPAIR). If the damage is extensive, it can induce APOPTOSIS.
Annotation: do not use /drug eff & /rad eff for DNA damage induced by drugs or radiation; do not confuse with DNA FRAGMENTATION: see note there
Allowable Qualifiers: DE drug effects
ES ethics
GE genetics
IM immunology
PH physiology
RE radiation effects
Previous Indexing: DNA (1966-1986)
DNA Repair (1971-1986)
DNA Replication (1968-1986)
Public MeSH Note: 87
History Note: 87
Related: Mutation MeSH
Pyrimidine Dimers MeSH
DeCS ID: 19154
Unique ID: D004249
NLM Classification: QU 510
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1987/01/01
Date of Entry: 1986/06/19
Revision Date: 2016/06/17
DNA Damage - Preferred
Concept UI M0006649
Scope note Injuries to DNA that introduce deviations from its normal, intact structure and which may, if left unrepaired, result in a MUTATION or a block of DNA REPLICATION. These deviations may be caused by physical or chemical agents and occur by natural or unnatural, introduced circumstances. They include the introduction of illegitimate bases during replication or by deamination or other modification of bases; the loss of a base from the DNA backbone leaving an abasic site; single-strand breaks; double strand breaks; and intrastrand (PYRIMIDINE DIMERS) or interstrand crosslinking. Damage can often be repaired (DNA REPAIR). If the damage is extensive, it can induce APOPTOSIS.
Preferred term DNA Damage
Entry term(s) DNA Damages
DNA Injuries
DNA Injury
Damage, DNA
Damages, DNA
Injuries, DNA
Injury, DNA
Genotoxic Stress - Narrower
Concept UI M0445010
Scope note DNA DAMAGE in vivo.
Preferred term Genotoxic Stress
Entry term(s) Genotoxic Stresses
Stress, Genotoxic
Stresses, Genotoxic



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