ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT Investigative Techniques [E05] Investigative Techniques Genetic Techniques [E05.393] Genetic Techniques Cellular Reprogramming Techniques [E05.393.085] Cellular Reprogramming Techniques Chromatin Immunoprecipitation [E05.393.170] Chromatin Immunoprecipitation Chromosome Mapping [E05.393.183] Chromosome Mapping Cloning, Molecular [E05.393.220] Cloning, Molecular Cloning, Organism [E05.393.240] Cloning, Organism Contig Mapping [E05.393.260] Contig Mapping Crosses, Genetic [E05.393.281] Crosses, Genetic Cytogenetic Analysis [E05.393.285] Cytogenetic Analysis DNA Fingerprinting [E05.393.290] DNA Fingerprinting DNA Footprinting [E05.393.300] DNA Footprinting Gene Expression Profiling [E05.393.332] Gene Expression Profiling Gene Targeting [E05.393.335] Gene Targeting Gene Transfer Techniques [E05.393.350] Gene Transfer Techniques Genetic Association Studies [E05.393.385] Genetic Association Studies Genetic Engineering [E05.393.420] Genetic Engineering Genetic Testing [E05.393.435] Genetic Testing Genotyping Techniques [E05.393.442] Genotyping Techniques In Situ Nick-End Labeling [E05.393.475] In Situ Nick-End Labeling Molecular Diagnostic Techniques [E05.393.520] Molecular Diagnostic Techniques Molecular Epidemiology [E05.393.522] Molecular Epidemiology Molecular Typing [E05.393.542] Molecular Typing Mutagenicity Tests [E05.393.560] Mutagenicity Tests Nuclease Protection Assays [E05.393.600] Nuclease Protection Assays Nucleic Acid Amplification Techniques [E05.393.620] Nucleic Acid Amplification Techniques Nucleic Acid Denaturation [E05.393.640] Nucleic Acid Denaturation Nucleic Acid Hybridization [E05.393.661] Nucleic Acid Hybridization Optogenetics [E05.393.667] Optogenetics Pedigree [E05.393.673] Pedigree Restriction Mapping [E05.393.712] Restriction Mapping Reverse Genetics [E05.393.731] Reverse Genetics Sequence Alignment [E05.393.751] Sequence Alignment Sequence Analysis [E05.393.760] Sequence Analysis Viral Pseudotyping [E05.393.880] Viral Pseudotyping PHENOMENA AND PROCESSES Chemical Phenomena [G02] Chemical Phenomena Biochemical Phenomena [G02.111] Biochemical Phenomena Acid-Base Equilibrium [G02.111.007] Acid-Base Equilibrium Acylation [G02.111.012] Acylation Aerobiosis [G02.111.017] Aerobiosis Agglutination [G02.111.026] Agglutination Alkylation [G02.111.035] Alkylation Allosteric Regulation [G02.111.044] Allosteric Regulation Amination [G02.111.053] Amination Anaerobiosis [G02.111.062] Anaerobiosis Autotrophic Processes [G02.111.071] Autotrophic Processes Base Composition [G02.111.080] Base Composition Binding, Competitive [G02.111.084] Binding, Competitive Biocatalysis [G02.111.086] Biocatalysis Biomineralization [G02.111.092] Biomineralization Biosynthetic Pathways [G02.111.098] Biosynthetic Pathways Biotinylation [G02.111.109] Biotinylation Body Composition [G02.111.130] Body Composition Brain Chemistry [G02.111.150] Brain Chemistry Carbohydrate Metabolism [G02.111.158] Carbohydrate Metabolism Citric Acid Cycle [G02.111.165] Citric Acid Cycle Cyclization [G02.111.180] Cyclization Dealkylation [G02.111.188] Dealkylation Deamination [G02.111.192] Deamination Decarboxylation [G02.111.195] Decarboxylation DNA Cleavage [G02.111.210] DNA Cleavage DNA Methylation [G02.111.218] DNA Methylation DNA Repair [G02.111.222] DNA Repair DNA Replication [G02.111.225] DNA Replication Down-Regulation [G02.111.240] Down-Regulation Electron Transport [G02.111.248] Electron Transport Energy Transfer [G02.111.255] Energy Transfer Enzyme Activation [G02.111.263] Enzyme Activation Esterification [G02.111.270] Esterification Halogenation [G02.111.323] Halogenation Heterotrophic Processes [G02.111.375] Heterotrophic Processes Hydrogenation [G02.111.380] Hydrogenation Hydroxylation [G02.111.385] Hydroxylation Kinetics [G02.111.490] Kinetics Lipid Peroxidation [G02.111.515] Lipid Peroxidation Lipogenesis [G02.111.528] Lipogenesis Lipolysis [G02.111.534] Lipolysis Lipoylation [G02.111.540] Lipoylation Melanogenesis [G02.111.545] Melanogenesis Membrane Fluidity [G02.111.550] Membrane Fluidity Molecular Mimicry [G02.111.560] Molecular Mimicry Molecular Structure [G02.111.570] Molecular Structure Nitrogen Cycle [G02.111.587] Nitrogen Cycle Nitrosation [G02.111.595] Nitrosation Nucleic Acid Denaturation [G02.111.603] Nucleic Acid Denaturation Nucleic Acid Hybridization [G02.111.611] Nucleic Acid Hybridization Nucleic Acid Renaturation [G02.111.619] Nucleic Acid Renaturation Osmoregulation [G02.111.635] Osmoregulation Osmosis [G02.111.655] Osmosis Peptide Biosynthesis [G02.111.660] Peptide Biosynthesis Phosphorylation [G02.111.665] Phosphorylation Phototrophic Processes [G02.111.669] Phototrophic Processes Prenylation [G02.111.672] Prenylation Protein Aggregation, Pathological [G02.111.675] Protein Aggregation, Pathological Protein Binding [G02.111.679] Protein Binding Protein Folding [G02.111.688] Protein Folding Protein Modification, Translational [G02.111.691] Protein Modification, Translational Protein Multimerization [G02.111.694] Protein Multimerization Protein Stability [G02.111.700] Protein Stability Proteolysis [G02.111.720] Proteolysis Proteostasis [G02.111.730] Proteostasis RNA Cleavage [G02.111.740] RNA Cleavage RNA Folding [G02.111.750] RNA Folding RNA Processing, Post-Transcriptional [G02.111.760] RNA Processing, Post-Transcriptional RNA Replication [G02.111.770] RNA Replication RNA Stability [G02.111.780] RNA Stability Sequence Homology [G02.111.810] Sequence Homology Signal Transduction [G02.111.820] Signal Transduction Structure-Activity Relationship [G02.111.830] Structure-Activity Relationship Substrate Cycling [G02.111.833] Substrate Cycling Substrate Specificity [G02.111.835] Substrate Specificity Transcription, Genetic [G02.111.873] Transcription, Genetic Up-Regulation [G02.111.905] Up-Regulation PHENOMENA AND PROCESSES Genetic Phenomena [G05] Genetic Phenomena Biological Evolution [G05.045] Biological Evolution Breeding [G05.090] Breeding Cell Division [G05.113] Cell Division Cellular Reprogramming [G05.135] Cellular Reprogramming Clonal Evolution [G05.158] Clonal Evolution Consanguinity [G05.180] Consanguinity DNA Cleavage [G05.193] DNA Cleavage DNA Damage [G05.200] DNA Damage DNA Methylation [G05.206] DNA Methylation DNA Packaging [G05.213] DNA Packaging DNA Repair [G05.219] DNA Repair DNA Replication [G05.226] DNA Replication DNA Transformation Competence [G05.232] DNA Transformation Competence Founder Effect [G05.285] Founder Effect Gene Expression [G05.297] Gene Expression Gene Expression Regulation [G05.308] Gene Expression Regulation Gene Frequency [G05.330] Gene Frequency Gene Order [G05.340] Gene Order Gene Pool [G05.342] Gene Pool Gene Rearrangement [G05.344] Gene Rearrangement Genetic Background [G05.346] Genetic Background Genetic Fitness [G05.347] Genetic Fitness Genetic Linkage [G05.348] Genetic Linkage Genetic Load [G05.350] Genetic Load Genetic Structures [G05.360] Genetic Structures Genetic Variation [G05.365] Genetic Variation Genomic Instability [G05.370] Genomic Instability Genotype [G05.380] Genotype Heredity [G05.390] Heredity Hybrid Vigor [G05.400] Hybrid Vigor Inbreeding Depression [G05.410] Inbreeding Depression Inheritance Patterns [G05.420] Inheritance Patterns Molecular Mimicry [G05.545] Molecular Mimicry Mutagenesis [G05.558] Mutagenesis Nucleic Acid Denaturation [G05.627] Nucleic Acid Denaturation Phenotype [G05.695] Phenotype Ploidies [G05.700] Ploidies Recombination, Genetic [G05.728] Recombination, Genetic RNA Cleavage [G05.755] RNA Cleavage RNA Replication [G05.769] RNA Replication Selection, Genetic [G05.783] Selection, Genetic Sequence Homology [G05.810] Sequence Homology Sex Determination Processes [G05.813] Sex Determination Processes Sex Ratio [G05.815] Sex Ratio Structural Homology, Protein [G05.820] Structural Homology, Protein Sympatry [G05.910] Sympatry Virus Integration [G05.935] Virus Integration

Nucleic Acid Denaturation - Preferred

Concept UI	M0015049
Scope note	Disruption of the secondary structure of nucleic acids by heat, extreme pH or chemical treatment. Double strand DNA is "melted" by dissociation of the non-covalent hydrogen bonds and hydrophobic interactions. Denatured DNA appears to be a single-stranded flexible structure. The effects of denaturation on RNA are similar though less pronounced and largely reversible.
Preferred term	Nucleic Acid Denaturation
Entry term(s)	Acid Denaturation, Nucleic Denaturation, Nucleic Acid Nucleic Acid Denaturations

RNA Denaturation - Narrower

Concept UI	M0498355
Preferred term	RNA Denaturation
Entry term(s)	Denaturation, RNA

DNA Denaturation - Narrower

Concept UI	M0498354
Preferred term	DNA Denaturation
Entry term(s)	DNA Melting Denaturation, DNA