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Descriptor English: DNA Repair
Descriptor Spanish: Reparación del ADN
Descriptor Portuguese: Reparo do DNA
Descriptor French: Réparation de l'ADN
Entry term(s): Base Excision Repair
Base Excision Repairs
Excision Repair
Excision Repair, Base
Excision Repair, Nucleotide
Excision Repairs
Nucleotide Excision Repair
Nucleotide Excision Repairs
Repair, Base Excision
Repair, Excision
Repairs, Base Excision
Tree number(s): G02.111.222
G05.219
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D004260
Scope note: The reconstruction of a continuous two-stranded DNA molecule without mismatch from a molecule which contained damaged regions. The major repair mechanisms are excision repair, in which defective regions in one strand are excised and resynthesized using the complementary base pairing information in the intact strand; photoreactivation repair, in which the lethal and mutagenic effects of ultraviolet light are eliminated; and post-replication repair, in which the primary lesions are not repaired, but the gaps in one daughter duplex are filled in by incorporation of portions of the other (undamaged) daughter duplex. Excision repair and post-replication repair are sometimes referred to as "dark repair" because they do not require light.
Annotation: coord IM with specific DNA (IM)
Allowable Qualifiers: DE drug effects
GE genetics
IM immunology
PH physiology
RE radiation effects
Previous Indexing: DNA (1966-1970)
DNA/biosynthesis (1966-1970)
Public MeSH Note: 74
History Note: 74(71)
Related: Pyrimidine Dimers MeSH
DeCS ID: 4328
Unique ID: D004260
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1974/01/01
Date of Entry: 1999/01/01
Revision Date: 2016/06/17
DNA Repair - Preferred
Concept UI M0006666
Scope note The reconstruction of a continuous two-stranded DNA molecule without mismatch from a molecule which contained damaged regions. The major repair mechanisms are excision repair, in which defective regions in one strand are excised and resynthesized using the complementary base pairing information in the intact strand; photoreactivation repair, in which the lethal and mutagenic effects of ultraviolet light are eliminated; and post-replication repair, in which the primary lesions are not repaired, but the gaps in one daughter duplex are filled in by incorporation of portions of the other (undamaged) daughter duplex. Excision repair and post-replication repair are sometimes referred to as "dark repair" because they do not require light.
Preferred term DNA Repair
Excision Repair - Narrower
Concept UI M0006667
Preferred term Excision Repair
Entry term(s) Excision Repairs
Repair, Excision
Nucleotide Excision Repair - Narrower
Concept UI M0006668
Preferred term Nucleotide Excision Repair
Entry term(s) Excision Repair, Nucleotide
Nucleotide Excision Repairs
Base Excision Repair - Narrower
Concept UI M0448966
Preferred term Base Excision Repair
Entry term(s) Base Excision Repairs
Excision Repair, Base
Repair, Base Excision
Repairs, Base Excision



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