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Descriptor English: Ivermectin
Descriptor Spanish: Ivermectina
Descriptor ivermectina
Scope note: Mezcla principalmente de avermectina H2B1a (RN 71827-03-7) con algo de avermectina H2B1b (RN 70209-81-3), que son macrólidos de STREPTOMYCES avermitilis. Se une al canal de cloro dependiente del glutamato y causa un aumento de la permeabilidad e hiperpolarización de las células nerviosas y musculares. Interactúa también con otros CANALES DEL CLORO. Es un antiparasitario de amplio espectro activo frente a microfilarias de ONCHOCERCA VOLVULUS pero no frente a la forma adulta.
Descriptor Portuguese: Ivermectina
Descriptor French: Ivermectine
Entry term(s): Eqvalan
Ivomec
MK 933
MK-933
MK933
Mectizan
Stromectol
Tree number(s): D02.540.576.500.997
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D007559
Scope note: A mixture of mostly avermectin H2B1a (RN 71827-03-7) with some avermectin H2B1b (RN 70209-81-3), which are macrolides from STREPTOMYCES avermitilis. It binds glutamate-gated chloride channel to cause increased permeability and hyperpolarization of nerve and muscle cells. It also interacts with other CHLORIDE CHANNELS. It is a broad spectrum antiparasitic that is active against microfilariae of ONCHOCERCA VOLVULUS but not the adult form.
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Antiparasitic Agents
Insecticides
Registry Number: 70288-86-7
CAS Type 1 Name: Ivermectin
Previous Indexing: Anthelmintics (1966-1986)
Antinematodal Agents (1974-1986)
Antiprotozoal Agents (1966-1986)
Filaricides (1973-1986)
Insecticides (1966-1986)
Lactones (1966-1986)
Public MeSH Note: 1987; for MECTIZAN see IVERMECTIN 1987-1999
History Note: 1987; for MECTIZAN use IVERMECTIN (NM) 1987-1999
DeCS ID: 19221
Unique ID: D007559
NLM Classification: SF 918.I83
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1987/01/01
Date of Entry: 1986/06/16
Revision Date: 2016/07/01
Ivermectin - Preferred
Concept UI M0011815
Scope note A mixture of mostly avermectin H2B1a (RN 71827-03-7) with some avermectin H2B1b (RN 70209-81-3), which are macrolides from STREPTOMYCES avermitilis. It binds glutamate-gated chloride channel to cause increased permeability and hyperpolarization of nerve and muscle cells. It also interacts with other CHLORIDE CHANNELS. It is a broad spectrum antiparasitic that is active against microfilariae of ONCHOCERCA VOLVULUS but not the adult form.
Preferred term Ivermectin
Stromectol - Narrower
Concept UI M0479368
Scope note Oral preparation of ivermectin.
Preferred term Stromectol
Mectizan - Narrower
Concept UI M0331957
Preferred term Mectizan
MK-933 - Narrower
Concept UI M0331956
Preferred term MK-933
Entry term(s) MK 933
MK933
Eqvalan - Narrower
Concept UI M0331954
Preferred term Eqvalan
Ivomec - Narrower
Concept UI M0331955
Preferred term Ivomec



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