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Descriptor English: Cholera Toxin
Descriptor Spanish: Toxina del Cólera
Descriptor toxina del cólera
Entry term(s) coleragenoide
colerágeno
enterotoxina colérica CT
exotoxina colérica
procoleragenoide
protómero A de la toxina del cólera
protómero B de la toxina del cólera
subunidad A de la toxina del cólera
subunidad B de la toxina del cólera
toxina A del cólera
toxina B del cólera
Scope note: Enterotoxina de VIBRIO CHOLERAE. Está constituida por dos protómeros principales, la subunidad pesada (H) o subunidad A y el protómero B, formado por 5 subunidades ligeras (L) o subunidades B. La subunidad catalítica A se divide proteoliticamente en fragmentos A1 y A2. El fragmento A1 es una mono(ADP-ribosa) transferasa. El protómero B une la toxina del cólera a las células epiteliales del intestino y facilita la captación del fragmento A1. La transferencia catalizada por A1 de ADP RIBOSA a las subunidades alfa de las PROTEÍNAS heterotriméricas G activa la producción de AMP CÍCLICO. Se piensa que las concentraciones elevadas de AMP cíclico modulan la secreción de líquido y electrólitos desde las células de las criptas intestinales.
Descriptor Portuguese: Toxina da Cólera
Descriptor French: Toxine cholérique
Entry term(s): CT, Cholera Enterotoxin
Cholera Enterotoxin CT
Cholera Exotoxin
Cholera Toxin A
Cholera Toxin A Subunit
Cholera Toxin B
Cholera Toxin B Subunit
Cholera Toxin Protomer A
Cholera Toxin Protomer B
Cholera Toxin Subunit A
Cholera Toxin Subunit B
Choleragen
Choleragenoid
Enterotoxin CT, Cholera
Exotoxin, Cholera
Procholeragenoid
Toxin A, Cholera
Toxin B, Cholera
Toxin, Cholera
Tree number(s): D08.811.913.400.725.115.180
D23.946.123.194
D23.946.330.150
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D002772
Scope note: An ENTEROTOXIN from VIBRIO CHOLERAE. It consists of two major protomers, the heavy (H) or A subunit and the B protomer which consists of 5 light (L) or B subunits. The catalytic A subunit is proteolytically cleaved into fragments A1 and A2. The A1 fragment is a MONO(ADP-RIBOSE) TRANSFERASE. The B protomer binds cholera toxin to intestinal epithelial cells and facilitates the uptake of the A1 fragment. The A1 catalyzed transfer of ADP-RIBOSE to the alpha subunits of heterotrimeric G PROTEINS activates the production of CYCLIC AMP. Increased levels of cyclic AMP are thought to modulate release of fluid and electrolytes from intestinal crypt cells.
Annotation: /antag permitted but consider also ANTITOXINS
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Adjuvants, Immunologic
Poisons
Registry Number: 9012-63-9
Previous Indexing: Bacterial Proteins (1966-1977)
Bacterial Toxins (1977)
Enterotoxins (1966-1977)
Toxins (1966-1967)
Public MeSH Note: 78
History Note: 78
DeCS ID: 2822
Unique ID: D002772
NLM Classification: WC 262
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1978/01/01
Date of Entry: 1977/04/22
Revision Date: 2020/05/27
Cholera Toxin - Preferred
Concept UI M0004245
Scope note An ENTEROTOXIN from VIBRIO CHOLERAE. It consists of two major protomers, the heavy (H) or A subunit and the B protomer which consists of 5 light (L) or B subunits. The catalytic A subunit is proteolytically cleaved into fragments A1 and A2. The A1 fragment is a MONO(ADP-RIBOSE) TRANSFERASE. The B protomer binds cholera toxin to intestinal epithelial cells and facilitates the uptake of the A1 fragment. The A1 catalyzed transfer of ADP-RIBOSE to the alpha subunits of heterotrimeric G PROTEINS activates the production of CYCLIC AMP. Increased levels of cyclic AMP are thought to modulate release of fluid and electrolytes from intestinal crypt cells.
Preferred term Cholera Toxin
Entry term(s) CT, Cholera Enterotoxin
Cholera Enterotoxin CT
Cholera Exotoxin
Choleragen
Enterotoxin CT, Cholera
Exotoxin, Cholera
Toxin, Cholera
Choleragenoid - Narrower
Concept UI M0004246
Scope note An ENTEROTOXIN from VIBRIO CHOLERAE. It consists of two major protomers, the heavy (H) or A subunit and the B protomer which consists of 5 light (L) or B subunits. The catalytic A subunit is proteolytically cleaved into fragments A1 and A2. The A1 fragment is a MONO(ADP-RIBOSE) TRANSFERASE. The B protomer binds cholera toxin to intestinal epithelial cells and facilitates the uptake of the A1 fragment. The A1 catalyzed transfer of ADP-RIBOSE to the alpha subunits of heterotrimeric G PROTEINS activates the production of CYCLIC AMP. Increased levels of cyclic AMP are thought to modulate release of fluid and electrolytes from intestinal crypt cells.
Preferred term Choleragenoid
Entry term(s) Cholera Toxin B
Cholera Toxin B Subunit
Cholera Toxin Protomer B
Cholera Toxin Subunit B
Toxin B, Cholera
Procholeragenoid - Narrower
Concept UI M0004250
Scope note An ENTEROTOXIN from VIBRIO CHOLERAE. It consists of two major protomers, the heavy (H) or A subunit and the B protomer which consists of 5 light (L) or B subunits. The catalytic A subunit is proteolytically cleaved into fragments A1 and A2. The A1 fragment is a MONO(ADP-RIBOSE) TRANSFERASE. The B protomer binds cholera toxin to intestinal epithelial cells and facilitates the uptake of the A1 fragment. The A1 catalyzed transfer of ADP-RIBOSE to the alpha subunits of heterotrimeric G PROTEINS activates the production of CYCLIC AMP. Increased levels of cyclic AMP are thought to modulate release of fluid and electrolytes from intestinal crypt cells.
Preferred term Procholeragenoid
Cholera Toxin Protomer A - Narrower
Concept UI M0004247
Scope note An ENTEROTOXIN from VIBRIO CHOLERAE. It consists of two major protomers, the heavy (H) or A subunit and the B protomer which consists of 5 light (L) or B subunits. The catalytic A subunit is proteolytically cleaved into fragments A1 and A2. The A1 fragment is a MONO(ADP-RIBOSE) TRANSFERASE. The B protomer binds cholera toxin to intestinal epithelial cells and facilitates the uptake of the A1 fragment. The A1 catalyzed transfer of ADP-RIBOSE to the alpha subunits of heterotrimeric G PROTEINS activates the production of CYCLIC AMP. Increased levels of cyclic AMP are thought to modulate release of fluid and electrolytes from intestinal crypt cells.
Preferred term Cholera Toxin Protomer A
Entry term(s) Cholera Toxin A
Cholera Toxin A Subunit
Cholera Toxin Subunit A
Toxin A, Cholera



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