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Descriptor English: Diphtheria Toxin
Descriptor Spanish: Toxina Diftérica
Descriptor toxina diftérica
Entry term(s) toxina de Corynebacterium diphtheriae
Scope note: Polipéptido de ribosilación del ADP producido por CORYNEBACTERIUM DIPHTHERIAE que causa los signos y síntomas de la DIFTERIA. Puede escindirse en dos dominios desiguales: el más pequeño, el dominio A catalítico, es la porción mortal y contiene MONO(ADP-RIBOSA)-TRANSFERASAS, que transfieren ADP RIBOSA al FACTOR 2 DE ELONGACIÓN DE PÉPTIDOS, inhibiendo así la síntesis proteica; y el dominio B, de mayor tamaño, necesario para la entrada en las células.
Descriptor Portuguese: Toxina Diftérica
Descriptor French: Toxine diphtérique
Entry term(s): Corynebacterium Diphtheriae Toxin
Toxin, Corynebacterium Diphtheriae
Tree number(s): D08.811.913.400.725.115.220
D23.946.123.305
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D004167
Scope note: An ADP-ribosylating polypeptide produced by CORYNEBACTERIUM DIPHTHERIAE that causes the signs and symptoms of DIPHTHERIA. It can be broken into two unequal domains: the smaller, catalytic A domain is the lethal moiety and contains MONO(ADP-RIBOSE) TRANSFERASES which transfers ADP RIBOSE to PEPTIDE ELONGATION FACTOR 2 thereby inhibiting protein synthesis; and the larger B domain that is needed for entry into cells.
Annotation: /antag permitted but consider also DIPHTHERIA ANTITOXIN
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Poisons
Related: Diphtheria Toxoid MeSH
DeCS ID: 4224
Unique ID: D004167
NLM Classification: WC 320
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1966/01/01
Date of Entry: 1999/01/01
Revision Date: 2007/07/09
Diphtheria Toxin - Preferred
Concept UI M0006522
Scope note An ADP-ribosylating polypeptide produced by CORYNEBACTERIUM DIPHTHERIAE that causes the signs and symptoms of DIPHTHERIA. It can be broken into two unequal domains: the smaller, catalytic A domain is the lethal moiety and contains MONO(ADP-RIBOSE) TRANSFERASES which transfers ADP RIBOSE to PEPTIDE ELONGATION FACTOR 2 thereby inhibiting protein synthesis; and the larger B domain that is needed for entry into cells.
Preferred term Diphtheria Toxin
Entry term(s) Corynebacterium Diphtheriae Toxin
Toxin, Corynebacterium Diphtheriae



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