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Descriptor English: Tetanus Toxin
Descriptor Spanish: Toxina Tetánica
Descriptor toxina tetánica
Entry term(s) neutotoxina clostridial
toxina de Clostridium tetani
Scope note: Proteína sintetizada por CLOSTRIDIUM TETANI como cadena única de aproximadamente 150 kDa con 35 por ciento de identidad de secuencias con la TOXINA BOTULÍNICA que se escinde en una cadena ligera y una cadena pesada unidas por un enlace disulfuro. La tetanolisina es el principio hemolítico y la tetanoespasmina es el principio neurotóxico. La toxina produce una desestructuración de los mecanismos inhibidores del SNC, permitiendo de este modo una actividad nerviosa sin control, lo que lleva a CONVULSIONES fatales.
Descriptor Portuguese: Toxina Tetânica
Descriptor French: Toxine tétanique
Entry term(s): Clostridial Neurotoxin
Clostridium tetani Toxin
Neurotoxin, Clostridial
Tetanus Toxins
Toxin, Clostridium tetani
Toxin, Tetanus
Toxins, Tetanus
Tree number(s): D12.776.097.872
D23.946.123.893
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D013744
Scope note: Protein synthesized by CLOSTRIDIUM TETANI as a single chain of ~150 kDa with 35% sequence identity to BOTULINUM TOXIN that is cleaved to a light and a heavy chain that are linked by a single disulfide bond. Tetanolysin is the hemolytic and tetanospasmin is the neurotoxic principle. The toxin causes disruption of the inhibitory mechanisms of the CNS, thus permitting uncontrolled nervous activity, leading to fatal CONVULSIONS.
Annotation: /antag permitted but consider also TETANUS ANTITOXIN
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Neurotoxins
Public MeSH Note: 65
History Note: 65
Related: Tetanus Antitoxin MeSH
DeCS ID: 14124
Unique ID: D013744
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1965/01/01
Date of Entry: 1999/01/01
Revision Date: 2005/06/30
Tetanus Toxin - Preferred
Concept UI M0021202
Scope note Protein synthesized by CLOSTRIDIUM TETANI as a single chain of ~150 kDa with 35% sequence identity to BOTULINUM TOXIN that is cleaved to a light and a heavy chain that are linked by a single disulfide bond. Tetanolysin is the hemolytic and tetanospasmin is the neurotoxic principle. The toxin causes disruption of the inhibitory mechanisms of the CNS, thus permitting uncontrolled nervous activity, leading to fatal CONVULSIONS.
Preferred term Tetanus Toxin
Entry term(s) Clostridium tetani Toxin
Tetanus Toxins
Toxin, Clostridium tetani
Toxin, Tetanus
Toxins, Tetanus
Clostridial Neurotoxin - Narrower
Concept UI M0021203
Preferred term Clostridial Neurotoxin
Entry term(s) Neurotoxin, Clostridial



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