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Descriptor English: Zinc Fingers
Descriptor Spanish: Dedos de Zinc
Descriptor dedos de zinc
Entry term(s) dominios de unión a ADN dedos de zinc
motivos en dedos de zinc
Scope note: Motivos en las proteínas de unión a ADN y ARN cuyos aminoácidos se encuentran agrupados en una sola unidad estructural alrededor de un átomo de zinc. En el dedo de zinc clásico, hay un átomo de zinc rodeado de dos cisteínas y dos histidinas. Entre las cisteínas y las histidinas hay doce residuos que constituyen una yema de unión al ADN. Mediante variaciones en la composición de las secuencias en la yema y el número y espacio de las repeticiones en tándem del motivo, los dedos de zinc pueden formar muchos puntos de acoplamiento con secuencias específicas diferentes.
Descriptor Portuguese: Dedos de Zinco
Descriptor French: Doigts de zinc
Entry term(s): Finger, Zinc
Fingers, Zinc
Motif, Zinc Finger
Motifs, Zinc Finger
Zinc Finger
Zinc Finger DNA Binding Domains
Zinc Finger DNA-Binding Domains
Zinc Finger Motif
Zinc Finger Motifs
Tree number(s): G02.111.570.820.709.275.500.985
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D016335
Scope note: Motifs in DNA- and RNA-binding proteins whose amino acids are folded into a single structural unit around a zinc atom. In the classic zinc finger, one zinc atom is bound to two cysteines and two histidines. In between the cysteines and histidines are 12 residues which form a DNA binding fingertip. By variations in the composition of the sequences in the fingertip and the number and spacing of tandem repeats of the motif, zinc fingers can form a large number of different sequence specific binding sites.
Allowable Qualifiers: DE drug effects
GE genetics
IM immunology
PH physiology
RE radiation effects
Previous Indexing: Amino Acid Sequence (1987-1990)
DNA-Binding Proteins (1987-1990)
Molecular Sequence Data (1988-1990)
Public MeSH Note: 91
History Note: 91
DeCS ID: 29155
Unique ID: D016335
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1991/01/01
Date of Entry: 1990/05/29
Revision Date: 2017/06/30
Zinc Fingers - Preferred
Concept UI M0024968
Scope note Motifs in DNA- and RNA-binding proteins whose amino acids are folded into a single structural unit around a zinc atom. In the classic zinc finger, one zinc atom is bound to two cysteines and two histidines. In between the cysteines and histidines are 12 residues which form a DNA binding fingertip. By variations in the composition of the sequences in the fingertip and the number and spacing of tandem repeats of the motif, zinc fingers can form a large number of different sequence specific binding sites.
Preferred term Zinc Fingers
Entry term(s) Finger, Zinc
Fingers, Zinc
Motif, Zinc Finger
Motifs, Zinc Finger
Zinc Finger
Zinc Finger Motif
Zinc Finger Motifs
Zinc Finger DNA-Binding Domains - Narrower
Concept UI M000631471
Preferred term Zinc Finger DNA-Binding Domains
Entry term(s) Zinc Finger DNA Binding Domains



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