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Descriptor English: Fusion Proteins, bcr-abl
Descriptor Spanish: Proteínas de Fusión bcr-abl
Descriptor proteínas de fusión bcr-abl
Entry term(s) proteína de fusión bcr-abl
proteína oncogénica p185(bcr-abl)
proteína oncogénica p190 (bcr-abl)
proteína oncogénica p210 (bcr-abl)
proteína oncogénica p230(bcr-abl)
proteínas de fusión p185(bcr-abl)
proteínas de fusión p190(bcr-abl)
proteínas de fusión p210(bcr-abl)
proteínas de fusión p230(bcr-abl)
Scope note: Productos de traducción de una fusión génica derivados de la TRANSLOCACIÓN CROMOSÓMICA de los GENES C-ABL al locus genético de la región del grupo de ruptura génica en el cromosoma 22. La proteína de fusión p210 (bcr-abl) se encuentra en pacientes con LEUCEMIA MIELÓGENA CRÓNICA BCR-ABL POSITIVA. La proteína de fusión p190 (bcr-abl) se encuentra en pacientes con LEUCEMIA LINFOMA DE CÉLULAS PRECURSORAS LINFOBLÁSTICAS. La activación del c-abl humano por la translocación cromosómica es esencialmente la misma a la activación del c-abl murino producida por la translocación víriva del VIRUS DE LA LEUCEMIA MURINA DE ABELSON.
Descriptor Portuguese: Proteínas de Fusão bcr-abl
Descriptor French: Protéines de fusion bcr-abl
Entry term(s): Bcr Abl Tyrosine Kinase
Bcr-Abl Tyrosine Kinase
Fusion Proteins, bcr abl
Kinase, Bcr-Abl Tyrosine
Oncogene Protein p185(bcr-abl)
Oncogene Protein p190(bcr-abl)
Oncogene Protein p210(bcr-abl)
Oncogene Protein p230(bcr-abl)
Tyrosine Kinase, Bcr-Abl
bcr abl Fusion Proteins
bcr-abl Fusion Protein
bcr-abl Fusion Proteins
p185(bcr-abl) Fusion Proteins
p190(bcr-abl) Fusion Proteins
p210(bcr-abl) Fusion Proteins
p230(bcr-abl) Fusion Proteins
Tree number(s): D08.811.913.696.620.682.725.500.500
D12.776.476.568.500.500
D12.776.602.500.500.100
D12.776.624.664.500.100
D12.776.624.664.700.171.500
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D016044
Scope note: Translation products of a fusion gene derived from CHROMOSOMAL TRANSLOCATION of C-ABL GENES to the genetic locus of the breakpoint cluster region gene on chromosome 22. Several different variants of the bcr-abl fusion proteins occur depending upon the precise location of the chromosomal breakpoint. These variants can be associated with distinct subtypes of leukemias such as PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; LEUKEMIA, MYELOGENOUS, CHRONIC, BCR-ABL POSITIVE; and NEUTROPHILIC LEUKEMIA, CHRONIC.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: EC 2.7.10.2
Previous Indexing: Neoplasm Proteins (1986-1989)
Public MeSH Note: 91; was BCR-ABL FUSION PROTEINS 1990
Online Note: use FUSION PROTEINS, BCR-ABL to search BCR-ABL FUSION PROTEINS 1990
History Note: 91; was BCR-ABL FUSION PROTEINS 1990
Related: Philadelphia Chromosome MeSH
DeCS ID: 29237
Unique ID: D016044
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1990/01/01
Date of Entry: 1989/05/25
Revision Date: 2013/07/08
Fusion Proteins, bcr-abl - Preferred
Concept UI M0024527
Scope note Translation products of a fusion gene derived from CHROMOSOMAL TRANSLOCATION of C-ABL GENES to the genetic locus of the breakpoint cluster region gene on chromosome 22. Several different variants of the bcr-abl fusion proteins occur depending upon the precise location of the chromosomal breakpoint. These variants can be associated with distinct subtypes of leukemias such as PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; LEUKEMIA, MYELOGENOUS, CHRONIC, BCR-ABL POSITIVE; and NEUTROPHILIC LEUKEMIA, CHRONIC.
Preferred term Fusion Proteins, bcr-abl
Entry term(s) Bcr Abl Tyrosine Kinase
Bcr-Abl Tyrosine Kinase
Fusion Proteins, bcr abl
Kinase, Bcr-Abl Tyrosine
Tyrosine Kinase, Bcr-Abl
bcr abl Fusion Proteins
bcr-abl Fusion Protein
bcr-abl Fusion Proteins
Oncogene Protein p190(bcr-abl) - Narrower
Concept UI M0024528
Preferred term Oncogene Protein p190(bcr-abl)
Entry term(s) p190(bcr-abl) Fusion Proteins
Oncogene Protein p230(bcr-abl) - Narrower
Concept UI M0537192
Preferred term Oncogene Protein p230(bcr-abl)
Entry term(s) p230(bcr-abl) Fusion Proteins
Oncogene Protein p185(bcr-abl) - Narrower
Concept UI M0537191
Preferred term Oncogene Protein p185(bcr-abl)
Entry term(s) p185(bcr-abl) Fusion Proteins
Oncogene Protein p210(bcr-abl) - Narrower
Concept UI M0024529
Preferred term Oncogene Protein p210(bcr-abl)
Entry term(s) p210(bcr-abl) Fusion Proteins



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