| Descriptor English: | Proto-Oncogene Proteins c-abl | ||||||
| Descriptor Spanish: |
Proteínas Proto-Oncogénicas c-abl
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| Descriptor Portuguese: | Proteínas Proto-Oncogênicas c-abl | ||||||
| Descriptor French: | Protéines proto-oncogènes c-abl | ||||||
| Entry term(s): |
Products, abl Proto-Oncogene Proteins abl, Proto-Oncogene Proto Oncogene Proteins abl Proto Oncogene Proteins c abl Proto-Oncogene Products, abl Proto-Oncogene Proteins abl Proto-Oncogene Proteins, abl abl Proto Oncogene Products abl Proto Oncogene Proteins abl Proto-Oncogene Products abl Proto-Oncogene Proteins abl, Proto-Oncogene Proteins c abl Proteins c-abl Proteins c-abl, Proto-Oncogene Proteins |
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| Tree number(s): |
D08.811.913.696.620.682.725.500 D12.776.476.568.500 D12.776.624.664.700.167 |
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| RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D016315 | ||||||
| Scope note: | Non-receptor tyrosine kinases encoded by the C-ABL GENES. They are distributed in both the cytoplasm and the nucleus. c-Abl plays a role in normal HEMATOPOIESIS especially of the myeloid lineage. Oncogenic transformation of c-abl arises when specific N-terminal amino acids are deleted, releasing the kinase from negative regulation. |
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| Allowable Qualifiers: |
AD administration & dosage AE adverse effects AG agonists AI antagonists & inhibitors AN analysis BI biosynthesis BL blood CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis DE drug effects DF deficiency EC economics GE genetics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PH physiology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UL ultrastructure UR urine |
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| Registry Number: | EC 2.7.10.2 | ||||||
| Previous Indexing: |
Neoplasm Proteins (1983-1985) Proto-Oncogene Proteins (1986-1990) |
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| Public MeSH Note: | 91 |
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| History Note: | 91 |
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| Related: |
Fusion Proteins, bcr-abl
MeSH | ||||||
| DeCS ID: | 29092 | ||||||
| Unique ID: | D016315 | ||||||
| Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||||
| Date Established: | 1991/01/01 | ||||||
| Date of Entry: | 1990/06/19 | ||||||
| Revision Date: | 2009/07/06 |
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CHEMICALS AND DRUGS
Enzymes and Coenzymes [D08]Enzymes and Coenzymes -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins
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Proto-Oncogene Proteins c-abl
- Preferred
| Concept UI |
M0024934 |
| Scope note | Non-receptor tyrosine kinases encoded by the C-ABL GENES. They are distributed in both the cytoplasm and the nucleus. c-Abl plays a role in normal HEMATOPOIESIS especially of the myeloid lineage. Oncogenic transformation of c-abl arises when specific N-terminal amino acids are deleted, releasing the kinase from negative regulation. |
| Preferred term | Proto-Oncogene Proteins c-abl |
| Entry term(s) |
Products, abl Proto-Oncogene Proteins abl, Proto-Oncogene Proto Oncogene Proteins abl Proto Oncogene Proteins c abl Proto-Oncogene Products, abl Proto-Oncogene Proteins abl Proto-Oncogene Proteins, abl abl Proto Oncogene Products abl Proto Oncogene Proteins abl Proto-Oncogene Products abl Proto-Oncogene Proteins abl, Proto-Oncogene Proteins c abl Proteins c-abl Proteins c-abl, Proto-Oncogene Proteins |
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