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Descriptor English: Swainsonine
Descriptor Spanish: Swainsonina
Descriptor swainsonina
Scope note: Alcaloide de indolizidina de la planta Swainsona canescens que es un potente inhibidor de la alfa-manosidasa. La swainsonina también exhibe actividad antimetastásica, antiproliferativa e inmunomoduladora.
Descriptor Portuguese: Swainsonina
Descriptor French: Tridolgosir
Entry term(s): Swainsonine, (1R-(2 beta,8a alpha))-Isomer
Swainsonine, (2 beta,8a alpha)-Isomer
Swainsonine, (8 alpha)-Isomer
Swainsonine, (8 alpha,8a alpha)-Isomer
Swainsonine, (8a alpha)-Isomer
Tree number(s): D03.132.830
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D017026
Scope note: An indolizidine alkaloid from the plant Swainsona canescens that is a potent alpha-mannosidase inhibitor. Swainsonine also exhibits antimetastatic, antiproliferative, and immunomodulatory activity.
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Adjuvants, Immunologic
Antineoplastic Agents, Phytogenic
Enzyme Inhibitors
Registry Number: RSY4RK37KQ
CAS Type 1 Name: 1,2,8-Indolizinetriol, octahydro-, (1S-(1alpha,2alpha,8beta,8abeta))-
Previous Indexing: Alkaloids (1980-1991)
Public MeSH Note: 92; SWAINSONINE was indexed under ALKALOIDS 1981-91
Online Note: use SWAINSONINE (NM) to search SWAINSONINE 1981-91
History Note: 92; was SWAINSONINE (NM) 1981-91
DeCS ID: 29798
Unique ID: D017026
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1992/01/01
Date of Entry: 1991/07/12
Revision Date: 2013/07/08
Swainsonine - Preferred
Concept UI M0025867
Scope note An indolizidine alkaloid from the plant Swainsona canescens that is a potent alpha-mannosidase inhibitor. Swainsonine also exhibits antimetastatic, antiproliferative, and immunomodulatory activity.
Preferred term Swainsonine
Swainsonine, (8a alpha)-Isomer - Narrower
Concept UI M0329437
Preferred term Swainsonine, (8a alpha)-Isomer
Swainsonine, (8 alpha)-Isomer - Narrower
Concept UI M0329321
Preferred term Swainsonine, (8 alpha)-Isomer
Swainsonine, (8 alpha,8a alpha)-Isomer - Narrower
Concept UI M0329320
Preferred term Swainsonine, (8 alpha,8a alpha)-Isomer
Swainsonine, (1R-(2 beta,8a alpha))-Isomer - Narrower
Concept UI M0329436
Preferred term Swainsonine, (1R-(2 beta,8a alpha))-Isomer
Swainsonine, (2 beta,8a alpha)-Isomer - Narrower
Concept UI M0329380
Preferred term Swainsonine, (2 beta,8a alpha)-Isomer



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