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Descriptor in English: Pyrrolizidine Alkaloids
Descriptor in Spanish: Alcaloides de Pirrolicidina
Descriptor in Portuguese: Alcaloides de Pirrolizidina
Descriptor in French: Alcaloïdes de type pyrrolizidine
Entry term(s): Alkaloids, Pyrrolizidine
Alkaloids, Senecio
Senecio Alkaloids
Tree number(s): D03.132.716
D03.633.100.772
Scope note: A group of ALKALOIDS, characterized by a nitrogen-containing necine, occurring mainly in plants of the BORAGINACEAE; COMPOSITAE; and LEGUMINOSAE plant families. They can be activated in the liver by hydrolysis of the ester and desaturation of the necine base to reactive electrophilic pyrrolic CYTOTOXINS.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
History Note: 73(71)
DeCS UI: 12200
Descriptor UI: D011763
Date Established: 1973/01/01
Date of Entry: 1999/01/01
Revision Date: 2016/05/31
Pyrrolizidine Alkaloids - Preferred
Concept UI M0018283
Scope note A group of ALKALOIDS, characterized by a nitrogen-containing necine, occurring mainly in plants of the BORAGINACEAE; COMPOSITAE; and LEGUMINOSAE plant families. They can be activated in the liver by hydrolysis of the ester and desaturation of the necine base to reactive electrophilic pyrrolic CYTOTOXINS.
Preferred term Pyrrolizidine Alkaloids
Entry term(s) Alkaloids, Pyrrolizidine
Senecio Alkaloids - Related but not broader or narrower
Concept UI M0018284
Preferred term Senecio Alkaloids
Entry term(s) Alkaloids, Senecio



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