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Descriptor English: tau Proteins
Descriptor Spanish: Proteínas tau
Descriptor proteínas tau
Scope note: Proteínas asociadas a los microtúbulos, que se expresan preferentemente en las neuronas. Las proteínas tau adoptan diversas isoformas y desempeñan un importante papel en el acoplamiento de monómeros de tubulina en los microtúbulos, asi como en el mantenimiento del citoesqueleto y el transporte axonal. La agregacion de paquetes específicos de proteínas tau en inclusiones filamentosas constituye la característica más común de las lesiones intraneuronales y fibrilares gliales (OVILLOS NEUROFIBRILARES, HILOS DE NEURÓPILO) en numerosos procesos neurodegenerativos (ENFERMEDAD DE ALZHEIMER, TAUOPATÍAS).
Descriptor Portuguese: Proteínas tau
Descriptor French: Protéines tau
Entry term(s): Protein, tau
Proteins, tau
tau Protein
Tree number(s): D12.776.220.600.450.510
D12.776.631.560.510
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D016875
Scope note: Microtubule-associated proteins that are mainly expressed in neurons. Tau proteins constitute several isoforms and play an important role in the assembly of tubulin monomers into microtubules and in maintaining the cytoskeleton and axonal transport. Aggregation of specific sets of tau proteins in filamentous inclusions is the common feature of intraneuronal and glial fibrillar lesions (NEUROFIBRILLARY TANGLES; NEUROPIL THREADS) in numerous neurodegenerative disorders (ALZHEIMER DISEASE; TAUOPATHIES).
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Previous Indexing: Microtubule-Associated Proteins (1986-1991)
Microtubules (1976-1985)
Public MeSH Note: 1992; TAU (NM) was indexed under MICROTUBULE-ASSOCIATED PROTEINS 1985-91 & under PROTEINS 1977-84
Online Note: use TAU PROTEINS (NM) to search TAU (NM) 1980-90
History Note: 1992; use TAU (NM) 1977-91
Related: Tauopathies MeSH
DeCS ID: 30290
Unique ID: D016875
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1992/01/01
Date of Entry: 1991/07/12
Revision Date: 2016/07/05
tau Proteins - Preferred
Concept UI M0025678
Scope note Microtubule-associated proteins that are mainly expressed in neurons. Tau proteins constitute several isoforms and play an important role in the assembly of tubulin monomers into microtubules and in maintaining the cytoskeleton and axonal transport. Aggregation of specific sets of tau proteins in filamentous inclusions is the common feature of intraneuronal and glial fibrillar lesions (NEUROFIBRILLARY TANGLES; NEUROPIL THREADS) in numerous neurodegenerative disorders (ALZHEIMER DISEASE; TAUOPATHIES).
Preferred term tau Proteins
Entry term(s) Protein, tau
Proteins, tau
tau Protein



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