Search
Descriptor English: KRIT1 Protein
Descriptor Spanish: Proteína KRIT1
Descriptor Portuguese: Proteína KRIT1
Descriptor French: Protéine KRIT1
Entry term(s): Cerebral Cavernous Malformations 1 Protein
Krev Interaction Trapped Protein 1
Tree number(s): D12.776.220.600.450.458
D12.776.624.664.700.119
D12.776.631.560.465
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D000075927
Scope note: A microtubule-associated protein consisting of four ANKYRIN REPEATS and a C-terminal FERM DOMAIN. It links the CYTOSKELETON to CELL JUNCTIONS via integrin cytoplasmic domain-associated protein-1 and plays an important role in regulating cell proliferation and integrity of endothelial cell junctions. It is also involved in REACTIVE OXYGEN SPECIES metabolism. Mutations in the KRIT1 gene are associated with type I CEREBRAL CAVERNOUS MALFORMATIONS.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Previous Indexing: Microtubule-Associated Proteins (1997-2017)
Proto-Oncogene Proteins (1997-2017)
Public MeSH Note: 2018
History Note: 2018
DeCS ID: 57104
Unique ID: D000075927
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2018/01/01
Date of Entry: 2017/07/11
Revision Date: 2017/06/29
KRIT1 Protein - Preferred
Concept UI M000631688
Scope note A microtubule-associated protein consisting of four ANKYRIN REPEATS and a C-terminal FERM DOMAIN. It links the CYTOSKELETON to CELL JUNCTIONS via integrin cytoplasmic domain-associated protein-1 and plays an important role in regulating cell proliferation and integrity of endothelial cell junctions. It is also involved in REACTIVE OXYGEN SPECIES metabolism. Mutations in the KRIT1 gene are associated with type I CEREBRAL CAVERNOUS MALFORMATIONS.
Preferred term KRIT1 Protein
Entry term(s) Cerebral Cavernous Malformations 1 Protein
Krev Interaction Trapped Protein 1



We want your feedback on the new DeCS / MeSH website

We invite you to complete a survey that will take no more than 3 minutes.


Go to survey