| Descriptor English: | KRIT1 Protein | ||||||
| Descriptor Spanish: |
Proteína KRIT1
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| Descriptor Portuguese: | Proteína KRIT1 | ||||||
| Descriptor French: | Protéine KRIT1 | ||||||
| Entry term(s): |
Cerebral Cavernous Malformations 1 Protein Krev Interaction Trapped Protein 1 |
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| Tree number(s): |
D12.776.220.600.450.458 D12.776.624.664.700.119 D12.776.631.560.465 |
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| RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D000075927 | ||||||
| Scope note: | A microtubule-associated protein consisting of four ANKYRIN REPEATS and a C-terminal FERM DOMAIN. It links the CYTOSKELETON to CELL JUNCTIONS via integrin cytoplasmic domain-associated protein-1 and plays an important role in regulating cell proliferation and integrity of endothelial cell junctions. It is also involved in REACTIVE OXYGEN SPECIES metabolism. Mutations in the KRIT1 gene are associated with type I CEREBRAL CAVERNOUS MALFORMATIONS. |
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| Allowable Qualifiers: |
AD administration & dosage AE adverse effects AG agonists AI antagonists & inhibitors AN analysis BI biosynthesis BL blood CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis DE drug effects DF deficiency EC economics GE genetics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PH physiology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UL ultrastructure UR urine |
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| Previous Indexing: |
Microtubule-Associated Proteins (1997-2017) Proto-Oncogene Proteins (1997-2017) |
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| Public MeSH Note: | 2018 |
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| History Note: | 2018 |
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| DeCS ID: | 57104 | ||||||
| Unique ID: | D000075927 | ||||||
| Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||||
| Date Established: | 2018/01/01 | ||||||
| Date of Entry: | 2017/07/11 | ||||||
| Revision Date: | 2017/06/29 |
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CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins
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KRIT1 Protein
- Preferred
| Concept UI |
M000631688 |
| Scope note | A microtubule-associated protein consisting of four ANKYRIN REPEATS and a C-terminal FERM DOMAIN. It links the CYTOSKELETON to CELL JUNCTIONS via integrin cytoplasmic domain-associated protein-1 and plays an important role in regulating cell proliferation and integrity of endothelial cell junctions. It is also involved in REACTIVE OXYGEN SPECIES metabolism. Mutations in the KRIT1 gene are associated with type I CEREBRAL CAVERNOUS MALFORMATIONS. |
| Preferred term | KRIT1 Protein |
| Entry term(s) |
Cerebral Cavernous Malformations 1 Protein Krev Interaction Trapped Protein 1 |
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