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Descriptor English: CD3 Complex
Descriptor Spanish: Complejo CD3
Descriptor complejo CD3
Entry term(s) antígeno CD3
antígenos CD3
antígenos T3
Scope note: Complejo formado al menos por cinco polipéptidos de unión a la membrana de los linfocitos T maduros que se asocian de forma no covalente con otro y con el receptor del linfocito T (RECEPTORES DE ANTÍGENOS DE LOS LINFOCITOS T). El complejo CD3 incluye las cadenas (subunidades) gamma, delta, épsilon, zeta y eta. Cuando el antígeno se une al receptor del linfocito T, el complejo CD3 transduce las señales activadoras al citoplasma del linfocito T. Las cadenas (subunidades) gamma y delta del antígeno CD3 están separadas de las cadenas gamma/delta del receptor del linfocito T (CADENAS GAMMA-DELTA DE LOS RECEPTORES DE ANTÍGENOS DE LOS LINFOCITOS T) y no están relacionadas con ellas.
Descriptor Portuguese: Complexo CD3
Descriptor French: Antigènes CD3
Entry term(s): Antigen, CD3
Antigen, T3
Antigens, CD3
Antigens, T3
CD3 Antigen
CD3 Antigens
T3 Antigen
T3 Antigens
T3 Complex
Tree number(s): D23.050.301.264.894.095
D23.101.100.894.095
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D017252
Scope note: Complex of at least five membrane-bound polypeptides in mature T-lymphocytes that are non-covalently associated with one another and with the T-cell receptor (RECEPTORS, ANTIGEN, T-CELL). The CD3 complex includes the gamma, delta, epsilon, zeta, and eta chains (subunits). When antigen binds to the T-cell receptor, the CD3 complex transduces the activating signals to the cytoplasm of the T-cell. The CD3 gamma and delta chains (subunits) are separate from and not related to the gamma/delta chains of the T-cell receptor (RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA).
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Previous Indexing: Antigens (1983-1984)
Antigens, Differentiation, T-Lymphocyte (1988-1992)
Antigens, Surface (1983-1987)
Receptors, Antigen, T-Cell (1990-1992)
Public MeSH Note: 2018; see ANTIGENS, CD3 1993-2017; CD3 COMPLEX was indexed under RECEPTORS, ANTIGEN, T-CELL 1990-92; under ANTIGENS, DIFFERENTIATION, T-LYMPHOCYTE 1988-92; under ANTIGENS, SURFACE 1983-87; and under ANTIGENS 1983-84; for T3 ANTIGENS see ANTIGENS, DIFFERENTIATION, T-LYMPHOCYTE 1988-92
History Note: 2018 (1993); use T3 ANTIGEN COMPLEX 1983-92; use ANTIGENS, DIFFERENTIATION, T-LYMPHOCYTE 1988-92
Related: Receptors, Antigen, T-Cell MeSH
DeCS ID: 30831
Unique ID: D017252
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1993/01/01
Date of Entry: 1992/05/07
Revision Date: 2017/06/02
CD3 Complex - Preferred
Concept UI M0026174
Scope note Complex of at least five membrane-bound polypeptides in mature T-lymphocytes that are non-covalently associated with one another and with the T-cell receptor (RECEPTORS, ANTIGEN, T-CELL). The CD3 complex includes the gamma, delta, epsilon, zeta, and eta chains (subunits). When antigen binds to the T-cell receptor, the CD3 complex transduces the activating signals to the cytoplasm of the T-cell. The CD3 gamma and delta chains (subunits) are separate from and not related to the gamma/delta chains of the T-cell receptor (RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA).
Preferred term CD3 Complex
Entry term(s) Antigen, CD3
Antigen, T3
Antigens, CD3
Antigens, T3
CD3 Antigen
CD3 Antigens
T3 Antigen
T3 Antigens
T3 Complex



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