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Descriptor English: CTLA-4 Antigen
Descriptor Spanish: Antígeno CTLA-4
Descriptor antígeno CTLA-4
Entry term(s) antígeno 4 de linfocitos T citotóxicos
proteína CTLA-4
Scope note: Receptor inhibidor de CÉLULAS T que está estrechamente relacionado con el ANTÍGENO CD28. Tiene especificidad por el ANTÍGENO CD80 y el ANTÍGENO CD86 y actúa como regulador negativo de la función periférica de las células T. El antígeno CLA-4 se cree juega un rol en la inducción de TOLERANCIA PERIFÉRICA.
Descriptor Portuguese: Antígeno CTLA-4
Descriptor French: Antigène CTLA-4
Entry term(s): Antigen, CD152
Antigen, CTLA-4
Antigens, CD152
CD152 Antigen
CD152 Antigens
CTLA 4 Antigen
CTLA 4 Protein
CTLA-4 Protein
Cytotoxic T Lymphocyte Antigen 4
Cytotoxic T Lymphocyte Associated Antigen 4
Cytotoxic T-Lymphocyte Antigen 4
Cytotoxic T-Lymphocyte-Associated Antigen 4
Tree number(s): D12.776.465.782
D12.776.543.750.705.222.750
D23.050.301.264.894.158
D23.101.100.894.158
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D060908
Scope note: An inhibitory T CELL receptor that is closely related to CD28 ANTIGEN. It has specificity for CD80 ANTIGEN and CD86 ANTIGEN and acts as a negative regulator of peripheral T cell function. CTLA-4 antigen is believed to play role in inducing PERIPHERAL TOLERANCE.
Allowable Qualifiers: AD administration & dosage
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CH chemistry
CL classification
DE drug effects
DF deficiency
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PH physiology
RE radiation effects
TU therapeutic use
UL ultrastructure
Public MeSH Note: 2012; CYTOTOXIC T-LYMPHOCYTE ANTIGEN 4 was indexed under ANTIGENS, CD 2008-2011, and under ANTIGENS, DIFFERENTIATION 1992-2007
History Note: 2012(1991)
Related: Abatacept MeSH
Ipilimumab MeSH
DeCS ID: 54634
Unique ID: D060908
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2012/01/01
Date of Entry: 2011/06/24
Revision Date: 2020/03/27
CTLA-4 Antigen - Preferred
Concept UI M0555800
Scope note An inhibitory T CELL receptor that is closely related to CD28 ANTIGEN. It has specificity for CD80 ANTIGEN and CD86 ANTIGEN and acts as a negative regulator of peripheral T cell function. CTLA-4 antigen is believed to play role in inducing PERIPHERAL TOLERANCE.
Preferred term CTLA-4 Antigen
Entry term(s) Antigen, CD152
Antigen, CTLA-4
Antigens, CD152
CD152 Antigen
CD152 Antigens
CTLA 4 Antigen
CTLA 4 Protein
CTLA-4 Protein
Cytotoxic T Lymphocyte Antigen 4
Cytotoxic T Lymphocyte Associated Antigen 4
Cytotoxic T-Lymphocyte Antigen 4
Cytotoxic T-Lymphocyte-Associated Antigen 4



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