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Descriptor English: Chaperonins
Descriptor Spanish: Chaperoninas
Descriptor chaperoninas
Entry term(s) chaperonina
complejo de chaperonina
Scope note: Clase de CHAPERONAS MOLECULARES de secuencias relacionadas, que se encuentran en las bacterias, mitocondrias y plástidos. Las chaperoninas son proteínas constitutivas abundantes, que aumentan en cantidad por causa de tensiones como el choque térmico, las infecciones bacterianas de macrófagos o el incremento en el contenido celular de proteínas no plegadas. Las chaperoninas bacterianas son inmunógenos importantes en infecciones bacterianas humanas debido a su acumulación durante el estrés de la infección. Dos miembros de esta clase de chaperonas son la CHAPERONINA 10 y la CHAPERONINA 60.
Descriptor Portuguese: Chaperoninas
Descriptor French: Chaperonines
Entry term(s): Complexe de chaperonines
Complexe de protéines chaperons
Famille des chaperonines
Protéines chaperons
Tree number(s): D08.811.277.040.025.142
D12.776.580.216.210
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D018833
Scope note: A family of multisubunit protein complexes that form into large cylindrical structures which bind to and encapsulate non-native proteins. Chaperonins utilize the energy of ATP hydrolysis to enhance the efficiency of PROTEIN FOLDING reactions and thereby help proteins reach their functional conformation. The family of chaperonins is split into GROUP I CHAPERONINS, and GROUP II CHAPERONINS, with each group having its own repertoire of protein subunits and subcellular preferences.
Annotation: general or unspecified; prefer specifics
Allowable Qualifiers: AD administration et posologie
AE effets indésirables
AG agonistes
AI antagonistes et inhibiteurs
AN analyse
BI biosynthèse
BL sang
CF liquide cérébrospinal
CH composition chimique
CL classification
CS synthèse chimique
DE effets des médicaments et des substances chimiques
DF déficit
EC économie
GE génétique
HI histoire
IM immunologie
IP isolement et purification
ME métabolisme
PD pharmacologie
PH physiologie
PK pharmacocinétique
PO intoxication
RE effets des radiations
SD ressources et distribution
ST normes
TO toxicité
TU usage thérapeutique
UL ultrastructure
UR urine
Registry Number: EC 3.6.1.-
DeCS ID: 32312
Unique ID: D018833
NLM Classification: QU 55.6
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1995/01/01
Date of Entry: 1994/05/31
Revision Date: 2020/05/27
Chaperonines - Preferred
Concept UI M0028187
Preferred term Chaperonines
Entry term(s) Famille des chaperonines
Protéines chaperons
Complexe de chaperonines - Narrower
Concept UI M0527154
Preferred term Complexe de chaperonines
Entry term(s) Complexe de protéines chaperons



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