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Descriptor English: Pinacidil
Descriptor Spanish: Pinacidilo
Descriptor pinacidilo
Scope note: Guanidina que abre los CANALES DEL POTASIO provocando vasodilatación periférica directa de las ARTERIOLAS. Reduce la PRESIÓN SANGUÍNEA y la resistencia periférica y produce retención de líquidos. (Martindale The Extra Pharmacopoeia, 31st ed).
Descriptor Portuguese: Pinacidil
Descriptor French: Pinacidil
Entry term(s): Anhydrous, Pinacidil
Pinacidil Anhydrous
Pindac
Tree number(s): D02.078.370.729
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D020110
Scope note: A guanidine that opens POTASSIUM CHANNELS producing direct peripheral vasodilatation of the ARTERIOLES. It reduces BLOOD PRESSURE and peripheral resistance and produces fluid retention. (Martindale The Extra Pharmacopoeia, 31st ed)
Allowable Qualifiers: AA analogs & derivatives
AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
EC economics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
Pharm Action: Antihypertensive Agents
Vasodilator Agents
Membrane Transport Modulators
Registry Number: 7B0ZZH8P2W
CAS Type 1 Name: Guanidine, N''-cyano-N-4-pyridinyl-N'-(1,2,2-trimethylpropylmonohydrate), (+-)-
Previous Indexing: Guanidines (1983-1998)
Pyridines (1980-1982)
Public MeSH Note: 99; PINACIDIL was indexed under GUANIDINES 1983-98 & PYRIDINES 1980-82
History Note: 99; use PINACIDIL (NM) 1980-98
DeCS ID: 33787
Unique ID: D020110
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1999/01/01
Date of Entry: 1998/06/10
Revision Date: 2013/07/08
Pinacidil - Preferred
Concept UI M0029848
Scope note A guanidine that opens POTASSIUM CHANNELS producing direct peripheral vasodilatation of the ARTERIOLES. It reduces BLOOD PRESSURE and peripheral resistance and produces fluid retention. (Martindale The Extra Pharmacopoeia, 31st ed)
Preferred term Pinacidil
Pinacidil Anhydrous - Narrower
Concept UI M0329070
Preferred term Pinacidil Anhydrous
Entry term(s) Anhydrous, Pinacidil
Pindac - Narrower
Concept UI M0350968
Preferred term Pindac



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