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Descriptor English: DNA Gyrase
Descriptor Spanish: Girasa de ADN
Descriptor ADN girasa
Entry term(s) proteína girasa A
proteína girasa B
subunidad A de ADN girasa
subunidad B de ADN girasa
Scope note: ADN topoisomerasa II bacteriana que cataliza la rotura dependiente del ATP de ambas hebras del ADN, el paso de las hebras sin escindir a través de las roturas y la nueva unión de las hebras rotas. La girasa se une al ADN como un heterotetrámero que consta de dos subunidades A y dos subunidades B. En presencia de ATP la girasa convierte el ADN de doble hélice circular en una superhélice. En ausencia de ATP el ADN superenrollado es relajado por la ADN girasa.
Descriptor Portuguese: DNA Girase
Descriptor French: DNA gyrase
Entry term(s): DNA Gyrase A Subunit
DNA Gyrase B Subunit
DNA-Gyrase
GyrA Protein
GyrB Protein
Tree number(s): D08.811.399.403.741.149
D12.776.097.237
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D027081
Scope note: A bacterial DNA topoisomerase II that catalyzes ATP-dependent breakage of both strands of DNA, passage of the unbroken strands through the breaks, and rejoining of the broken strands. Gyrase binds to DNA as a heterotetramer consisting of two A and two B subunits. In the presence of ATP, gyrase is able to convert the relaxed circular DNA duplex into a superhelix. In the absence of ATP, supercoiled DNA is relaxed by DNA gyrase.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Entry Combination: antagonists & inhibitors:Topoisomerase II Inhibitors
Registry Number: EC 5.99.1.3
Previous Indexing: DNA Topoisomerases (1977-1978)
DNA Topoisomerases, Type II (1979-2001)
DNA, Circular (1976-1977)
Public MeSH Note: 2002; see DNA TOPOISOMERASE (ATP-HYDROLYZING) 1994-2001, see DNA GYRASE 1980-1993; GYRA PROTEIN was indexed under DNA TOPOISOMERASE (ATP-HYDROLYZING) (NM) 1992-2001; GYRB PROTEIN was indexed under DNA TOPOISOMERASE (ATP-HYDROLYZING) (NM) 1991-2001
History Note: 2002; use DNA TOPOISOMERASE (ATP-HYDROLYZING) 1994-2001, use DNA GYRASE 1980-1993; for GYRA PROTEIN use DNA TOPOISOMERASE (ATP-HYDROLYZING) (NM) 1992-2001; GYRB PROTEIN use DNA TOPOISOMERASE (ATP-HYDROLYZING) (NM) 1991-2001
DeCS ID: 36089
Unique ID: D027081
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2002/01/01
Date of Entry: 2001/07/25
Revision Date: 2013/07/08
DNA Gyrase - Preferred
Concept UI M0379516
Scope note A bacterial DNA topoisomerase II that catalyzes ATP-dependent breakage of both strands of DNA, passage of the unbroken strands through the breaks, and rejoining of the broken strands. Gyrase binds to DNA as a heterotetramer consisting of two A and two B subunits. In the presence of ATP, gyrase is able to convert the relaxed circular DNA duplex into a superhelix. In the absence of ATP, supercoiled DNA is relaxed by DNA gyrase.
Preferred term DNA Gyrase
Entry term(s) DNA-Gyrase
DNA Gyrase B Subunit - Narrower
Concept UI M0193335
Scope note One of the two subunits in DNA gyrase.
Preferred term DNA Gyrase B Subunit
Entry term(s) GyrB Protein
DNA Gyrase A Subunit - Narrower
Concept UI M0197847
Scope note One of the two subunits in DNA gyrase.
Preferred term DNA Gyrase A Subunit
Entry term(s) GyrA Protein



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