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Descriptor English: Leukocyte L1 Antigen Complex
Descriptor Spanish: Complejo de Antígeno L1 de Leucocito
Descriptor complejo antigénico leucocitario L1
Entry term(s) antígeno L1
proteína leucocitaria L1
Scope note: Miembro de la familia de proteínas S-100 que se halla presente en grandes concentraciones en la sangre y líquido intersticial en varios trastornos infecciosos, inflamatorios y malignos, como la artritis reumatoide, la enfermedad inflamatoria intestinal y la fibrosis quística. Es un complejo de una cadena ligera (CALGRANULINA A) y de una cadena pesada (CALGRANULINA B). L1 se une al calcio por medio de un motivo en mano-EF, y se ha demostrado que posee actividad antimicrobiana.
Descriptor Portuguese: Complexo Antígeno L1 Leucocitário
Descriptor French: Complexe antigénique L1 leucocytaire
Entry term(s): 27E10 Antigen
Antigen L1, Myelomonocytic
Antigen, 27E10
Antigen, L1
Calcium Binding Myeloid Protein P8,14
Calcium-Binding Myeloid Protein P8,14
Calgranulin
Calprotectin
L1 Antigen
L1 Protein, Leukocyte
Leukocyte L1 Protein
Migratory Inhibitory Factor Related Protein MRP
Migratory Inhibitory Factor-Related Protein MRP
Myelomonocytic Antigen L1
Tree number(s): D12.776.157.125.750.500
D12.776.631.658.750
D23.050.301.562
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D039841
Scope note: A member of the S-100 protein family that is present at high levels in the blood and interstitial fluid in several infectious, inflammatory, and malignant disorders, including rheumatoid arthritis, inflammatory bowel disease, and cystic fibrosis. It is a complex of a light chain (CALGRANULIN A) and a heavy chain (CALGRANULIN B). L1 binds calcium through an EF-hand motif, and has been shown to possess antimicrobial activity.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
DE drug effects
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PO poisoning
RE radiation effects
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Previous Indexing: Antigens, Surface (1984-1991)
Cell Adhesion Molecules, Neuronal (1992-1995)
Membrane Glycoproteins (1984-2002)
Neural Cell Adhesion Molecules (1996-2002)
Public MeSH Note: 2003; L1 ANTIGEN (now LEUKOCYTE L1 ANTIGEN COMPLEX) was indexed under MEMBRANE GLYCOPROTEINS 1984-2002, NEURAL CELL ADHESION MOLECULES 1996-2002, CELL ADHESION MOLECULES, NEURONAL 1992-1995 & ANTIGENS, SURFACE 1984-1991
History Note: 2003; use LEUKOCYTE L1 ANTIGEN COMPLEX (NM) 1984-2002
DeCS ID: 37387
Unique ID: D039841
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2003/01/01
Date of Entry: 2002/07/02
Revision Date: 2015/11/24
Leukocyte L1 Antigen Complex - Preferred
Concept UI M0122495
Scope note A member of the S-100 protein family that is present at high levels in the blood and interstitial fluid in several infectious, inflammatory, and malignant disorders, including rheumatoid arthritis, inflammatory bowel disease, and cystic fibrosis. It is a complex of a light chain (CALGRANULIN A) and a heavy chain (CALGRANULIN B). L1 binds calcium through an EF-hand motif, and has been shown to possess antimicrobial activity.
Preferred term Leukocyte L1 Antigen Complex
Entry term(s) 27E10 Antigen
Antigen L1, Myelomonocytic
Antigen, 27E10
Antigen, L1
Calcium Binding Myeloid Protein P8,14
Calcium-Binding Myeloid Protein P8,14
Calgranulin
Calprotectin
L1 Antigen
L1 Protein, Leukocyte
Leukocyte L1 Protein
Migratory Inhibitory Factor Related Protein MRP
Migratory Inhibitory Factor-Related Protein MRP
Myelomonocytic Antigen L1



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