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Descriptor English: Integrin alpha Chains
Descriptor Spanish: Cadenas alfa de Integrinas
Descriptor cadenas alfa de integrinas
Entry term(s) alfa-integrinas
integrinas alfa
Scope note: Subunidades alfa de heterodímeros de integrina (INTEGRINAS), que median en la especificidad de los ligandos. Existen aproximadamente 18 cadenas alfa diferentes, con una gran diversidad de secuencias. Varias cadenas se empalman también en isoformas alternativas. Poseen una porción extracelular larga (1.200 aminoácidos) que contiene un motivo MIDAS (metal ion-dependent adhesion site) y siete repeticiones en tándem de 60 aminoácidos, de los que los 4 últimos forman MOTIVOS EF HAND. La porción intracelular es corta, con excepción de la INTEGRINA ALFA 4.
Descriptor Portuguese: Cadeias alfa de Integrinas
Descriptor French: Intégrines alpha
Entry term(s): Integrin alpha Subunits
Integrins, alpha
alpha Chains, Integrin
alpha Integrins
Tree number(s): D12.776.543.750.705.408.100
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D039001
Scope note: The alpha subunits of integrin heterodimers (INTEGRINS), which mediate ligand specificity. There are approximately 18 different alpha chains, exhibiting great sequence diversity; several chains are also spliced into alternative isoforms. They possess a long extracellular portion (1200 amino acids) containing a MIDAS (metal ion-dependent adhesion site) motif, and seven 60-amino acid tandem repeats, the last 4 of which form EF HAND MOTIFS. The intracellular portion is short with the exception of INTEGRIN ALPHA4.
Allowable Qualifiers: AD administration & dosage
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CH chemistry
CL classification
DE drug effects
DF deficiency
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PH physiology
RE radiation effects
TU therapeutic use
UL ultrastructure
Previous Indexing: Integrins (1966-2002)
Public MeSH Note: 2003
History Note: 2003
DeCS ID: 37482
Unique ID: D039001
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2003/01/01
Date of Entry: 2002/07/02
Revision Date: 2013/07/09
Integrin alpha Chains - Preferred
Concept UI M0417909
Scope note The alpha subunits of integrin heterodimers (INTEGRINS), which mediate ligand specificity. There are approximately 18 different alpha chains, exhibiting great sequence diversity; several chains are also spliced into alternative isoforms. They possess a long extracellular portion (1200 amino acids) containing a MIDAS (metal ion-dependent adhesion site) motif, and seven 60-amino acid tandem repeats, the last 4 of which form EF HAND MOTIFS. The intracellular portion is short with the exception of INTEGRIN ALPHA4.
Preferred term Integrin alpha Chains
Entry term(s) Integrin alpha Subunits
Integrins, alpha
alpha Chains, Integrin
alpha Integrins



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