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Descriptor English: 3-alpha-Hydroxysteroid Dehydrogenase (B-Specific)
Descriptor Spanish: 3-alfa-Hidroxiesteroide Deshidrogenasa (B-Específica)
Descriptor 3-alfa-hidroxiesteroide deshidrogenasa (B-específica)
Entry term(s) 3-alfa-hidroxiesteroide-deshidrogenasa (B-específica)
Scope note: 3-hidroxiesteroide-deshidrogenasa que cataliza la reducción reversible de la DIHIDROTESTOSTERONA, un andrógeno activo, para formar 5-ALFA-ANDROSTANO-3 ALFA,17 BETA-DIOL. También tiene actividad respecto a otros 3-alfa-hidroxiesteroides y sobre la 9-hidroxiprostaglandina, 11-hidroxiprostaglandina y 15-hidroxiprostaglandina. La enzima es B-específica, en referencia a la orientación del NAD reducido o NADPH.
Descriptor Portuguese: 3-alfa-Hidroxiesteroide Desidrogenase (B-Específica)
Descriptor French: 3-alpha-Hydroxysteroid dehydrogenase (B-Specific)
Entry term(s): 3 alpha Hydroxysteroid Dehydrogenase
3 alpha Hydroxysteroid Oxidoreductase
3 alpha-Hydroxysteroid Dehydrogenase
3 alpha-Hydroxysteroid Dehydrogenase (B-Specific)
3 alpha-Hydroxysteroid Oxidoreductase
3alpha-Hydroxysteroid Dehydrogenase (B-specific)
5 alpha Dihydroprogesterone 3 alpha Hydroxysteroid Oxidoreductase
5 alpha-3 alpha-Hydroxysteroid Dehydrogenase
5 alpha-Dihydroprogesterone 3 alpha-Hydroxysteroid Oxidoreductase
5-DP-3 alpha-HSO
Dehydrogenase, 3 alpha-Hydroxysteroid
NADPH 5 alpha Dihydroprogesterone 3 alpha Hydroxysteroid Oxidoreductase
NADPH-5 alpha-Dihydroprogesterone 3 alpha-Hydroxysteroid Oxidoreductase
Oxidoreductase, 3 alpha-Hydroxysteroid
Tree number(s): D08.811.682.047.436.350.100
D08.811.682.047.820.186
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D045002
Scope note: A 3-hydroxysteroid dehydrogenase which catalyzes the reversible reduction of the active androgen, DIHYDROTESTOSTERONE to 5 ALPHA-ANDROSTANE-3 ALPHA,17 BETA-DIOL. It also has activity towards other 3-alpha-hydroxysteroids and on 9-, 11- and 15- hydroxyprostaglandins. The enzyme is B-specific in reference to the orientation of reduced NAD or NADPH.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: EC 1.1.1.50
Previous Indexing: 3-Hydroxysteroid Dehydrogenases (1979-2003)
Public MeSH Note: 2004; 3-ALPHA-HYDROXYSTEROID DEHYDROGENASE (B-SPECIFIC) was indexed under 3-HYDROXYSTEROID DEHYDROGENASES 1979-2003; 5 ALPHA-DIHYDROPROGESTERONE 3 ALPHA-HYDROSTEROID OXIDOREDUCTASE was indexed under 3-HYDROXYSTEROID DEHYDROGENASES 1981-2003
History Note: 2004; use 3-ALPHA-HYDROXYSTEROID DEHYDROGENASE (B-SPECIFIC) (NM) 1979-2003
DeCS ID: 38201
Unique ID: D045002
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2004/01/01
Date of Entry: 2003/07/09
Revision Date: 2013/07/08
3-alpha-Hydroxysteroid Dehydrogenase (B-Specific) - Preferred
Concept UI M0076298
Scope note A 3-hydroxysteroid dehydrogenase which catalyzes the reversible reduction of the active androgen, DIHYDROTESTOSTERONE to 5 ALPHA-ANDROSTANE-3 ALPHA,17 BETA-DIOL. It also has activity towards other 3-alpha-hydroxysteroids and on 9-, 11- and 15- hydroxyprostaglandins. The enzyme is B-specific in reference to the orientation of reduced NAD or NADPH.
Preferred term 3-alpha-Hydroxysteroid Dehydrogenase (B-Specific)
Entry term(s) 3 alpha Hydroxysteroid Dehydrogenase
3 alpha Hydroxysteroid Oxidoreductase
3 alpha-Hydroxysteroid Dehydrogenase
3 alpha-Hydroxysteroid Dehydrogenase (B-Specific)
3 alpha-Hydroxysteroid Oxidoreductase
3alpha-Hydroxysteroid Dehydrogenase (B-specific)
Dehydrogenase, 3 alpha-Hydroxysteroid
Oxidoreductase, 3 alpha-Hydroxysteroid
5 alpha-Dihydroprogesterone 3 alpha-Hydroxysteroid Oxidoreductase - Narrower
Concept UI M0090285
Preferred term 5 alpha-Dihydroprogesterone 3 alpha-Hydroxysteroid Oxidoreductase
Entry term(s) 5 alpha Dihydroprogesterone 3 alpha Hydroxysteroid Oxidoreductase
5 alpha-3 alpha-Hydroxysteroid Dehydrogenase
5-DP-3 alpha-HSO
NADPH 5 alpha Dihydroprogesterone 3 alpha Hydroxysteroid Oxidoreductase
NADPH-5 alpha-Dihydroprogesterone 3 alpha-Hydroxysteroid Oxidoreductase



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