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Descriptor English: Ketol-Acid Reductoisomerase
Descriptor Spanish: Cetoácido Reductoisomerasa
Descriptor cetoácido reductoisomerasa
Scope note: Enzima que cataliza la oxidación del (R)-2,3-dihidroxi-3-metilbutanoato a (S)-2-hidroxi-2-metil-3-oxobutanoato en presencia de NADP. Está implicada en la biosíntesis de la VALINA, LEUCINA, ISOLEUCINA, pentotenato y COENZIMA A. Esta enzima ha sido clasificada previamente como EC 1.1.1.89.
Descriptor Portuguese: Cetol-Ácido Redutoisomerase
Descriptor French: Ketol-acid reductoisomerase
Entry term(s): Acetohydroxy Acid Isomeroreductase
Acid Isomeroreductase, Acetohydroxy
Alpha Acetohydroxyacid Isomeroreductase
Alpha-Acetohydroxyacid Isomeroreductase
Dihydroxyisovalerate Dehydrogenase (Isomerizing)
Hydroxyacid Reductoisomerase
Isomeroreductase
Isomeroreductase, Acetohydroxy Acid
Isomeroreductase, Alpha-Acetohydroxyacid
Ketol Acid Reductoisomerase
Reductoisomerase, Hydroxyacid
Reductoisomerase, Ketol-Acid
Tree number(s): D08.811.682.047.820.487
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D050540
Scope note: An enzyme that catalyzes the oxidation of (R)-2,3-dihydroxy-3-methylbutanoate to (S)-2-hydroxy-2-methyl-3-oxobutanoate in the presence of NADP. It is involved in the biosynthesis of VALINE; LEUCINE; ISOLEUCINE; pentothenate and COENZYME A. This enzyme was formerly classified as EC 1.1.1.89.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: EC 1.1.1.86
Public MeSH Note: 2006; KETOL-ACID REDUCTOISOMERASE was indexed under ALCOHOL OXODOREDUCTASES 1983-2000, & under VALERATES 1970-1982
History Note: 2006(1980); use VALERATES 1970-1979
DeCS ID: 50599
Unique ID: D050540
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2006/01/01
Date of Entry: 2005/06/30
Revision Date: 2013/07/08
Ketol-Acid Reductoisomerase - Preferred
Concept UI M0076427
Scope note An enzyme that catalyzes the oxidation of (R)-2,3-dihydroxy-3-methylbutanoate to (S)-2-hydroxy-2-methyl-3-oxobutanoate in the presence of NADP. It is involved in the biosynthesis of VALINE; LEUCINE; ISOLEUCINE; pentothenate and COENZYME A. This enzyme was formerly classified as EC 1.1.1.89.
Preferred term Ketol-Acid Reductoisomerase
Entry term(s) Acetohydroxy Acid Isomeroreductase
Acid Isomeroreductase, Acetohydroxy
Alpha Acetohydroxyacid Isomeroreductase
Alpha-Acetohydroxyacid Isomeroreductase
Dihydroxyisovalerate Dehydrogenase (Isomerizing)
Hydroxyacid Reductoisomerase
Isomeroreductase
Isomeroreductase, Acetohydroxy Acid
Isomeroreductase, Alpha-Acetohydroxyacid
Ketol Acid Reductoisomerase
Reductoisomerase, Hydroxyacid
Reductoisomerase, Ketol-Acid



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