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Descriptor English: Isocitrate Dehydrogenase
Descriptor Spanish: Isocitrato Deshidrogenasa
Descriptor isocitrato deshidrogenasa
Entry term(s) NAD isocitrato deshidrogenasa
Scope note: Enzima de la clase de las oxidorreductasas que cataliza la conversión de isocitrato y NAD+ para dar lugar a 2-cetoglutarato, anhídrido carbónico y NADH. Se localiza en las mitocondrias. La enzima requiere Mg2+ o Mn2+; es activada por ADP, citrato y CA2+, e inhibida por NADH, NADPH, y ATP. La reacción es el paso clave limitador de la velocidad en el ciclo del ácido cítrico (tricarboxílico). (Dorland, 27th ed) (la enzima NADP+ es EC 1.1.1.42.) EC 1.1.1.41.
Descriptor Portuguese: Isocitrato Desidrogenase
Descriptor French: Isocitrate dehydrogenases
Entry term(s): Dehydrogenase, Isocitrate
Dehydrogenase, NAD Isocitrate
Isocitrate Dehydrogenase (NAD+)
Isocitrate Dehydrogenase I
Isocitrate Dehydrogenase, NAD
Isocitrate Dehydrogenase-I
NAD Isocitrate Dehydrogenase
Tree number(s): D08.811.682.047.820.475
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D007521
Scope note: An enzyme of the oxidoreductase class that catalyzes the conversion of isocitrate and NAD+ to yield 2-ketoglutarate, carbon dioxide, and NADH. It occurs in cell mitochondria. The enzyme requires Mg2+, Mn2+; it is activated by ADP, citrate, and Ca2+, and inhibited by NADH, NADPH, and ATP. The reaction is the key rate-limiting step of the citric acid (tricarboxylic) cycle. (From Dorland, 27th ed) (The NADP+ enzyme is EC 1.1.1.42.) EC 1.1.1.41.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: EC 1.1.1.41
CAS Type 1 Name: Isocitrate:NAD+ oxidoreductase (decarboxylating)
Public MeSH Note: 65
History Note: 65(63)
DeCS ID: 7688
Unique ID: D007521
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 1965/01/01
Date of Entry: 1999/01/01
Revision Date: 2013/07/08
Isocitrate Dehydrogenase - Preferred
Concept UI M0011751
Scope note An enzyme of the oxidoreductase class that catalyzes the conversion of isocitrate and NAD+ to yield 2-ketoglutarate, carbon dioxide, and NADH. It occurs in cell mitochondria. The enzyme requires Mg2+, Mn2+; it is activated by ADP, citrate, and Ca2+, and inhibited by NADH, NADPH, and ATP. The reaction is the key rate-limiting step of the citric acid (tricarboxylic) cycle. (From Dorland, 27th ed) (The NADP+ enzyme is EC 1.1.1.42.) EC 1.1.1.41.
Preferred term Isocitrate Dehydrogenase
Entry term(s) Dehydrogenase, Isocitrate
Dehydrogenase, NAD Isocitrate
Isocitrate Dehydrogenase (NAD+)
Isocitrate Dehydrogenase, NAD
NAD Isocitrate Dehydrogenase
Isocitrate Dehydrogenase-I - Narrower
Concept UI M0011752
Preferred term Isocitrate Dehydrogenase-I
Entry term(s) Isocitrate Dehydrogenase I



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