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Descriptor English: Homogentisate 1,2-Dioxygenase
Descriptor Spanish: Homogentisato 1,2-Dioxigenasa
Descriptor homogentisato 1,2-dioxigenasa
Scope note: Oxigenasa dependiente de Fe(II) mononuclear que cataliza la conversión del homogentisato a 4-maleilacetoacetato, el tercer paso de la vía del catabolismo de la TIROSINA. La deficiencia de esta enzima causa la ALCAPTONURIA, un trastorno autosómico recesivo caracterizado por aciduria homogentísica, OCRONOSIS y ARTRITIS. Esta enzima ha sido caracterizada previamente como EC 1.13.1.5 y EC 1.99.2.5.
Descriptor Portuguese: Homogentisato 1,2-Dioxigenase
Descriptor French: Homogentisate 1,2-dioxygenase
Entry term(s): 1,2-Dioxygenase, Homogentisate
Acid Oxidase, Homogentisic
Dioxygenase, Homogentisate
Homogentisate 1,2 Dioxygenase
Homogentisate Dioxygenase
Homogentisate Oxidase
Homogentisate Oxygenase
Homogentisic Acid Oxidase
Oxidase, Homogentisate
Oxidase, Homogentisic Acid
Oxygenase, Homogentisate
Tree number(s): D08.811.682.690.416.326
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D050560
Scope note: A mononuclear Fe(II)-dependent oxygenase, this enzyme catalyzes the conversion of homogentisate to 4-maleylacetoacetate, the third step in the pathway for the catabolism of TYROSINE. Deficiency in the enzyme causes ALKAPTONURIA, an autosomal recessive disorder, characterized by homogentisic aciduria, OCHRONOSIS and ARTHRITIS. This enzyme was formerly characterized as EC 1.13.1.5 and EC 1.99.2.5.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Registry Number: EC 1.13.11.5
Previous Indexing: Dioxygenases (1969-2005)
Public MeSH Note: 2006; HOMOGENTISATE 1,2-DIOXYGENASE was indexed under DIOXYGENASES 1969-2005, OXYGENASES 1983-2004, & under HOMOGENTISIC ACID 1973-1982
History Note: 2006(1969)
Related: Alkaptonuria MeSH
DeCS ID: 50654
Unique ID: D050560
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2006/01/01
Date of Entry: 2005/06/30
Revision Date: 2012/07/03
Homogentisate 1,2-Dioxygenase - Preferred
Concept UI M0076145
Scope note A mononuclear Fe(II)-dependent oxygenase, this enzyme catalyzes the conversion of homogentisate to 4-maleylacetoacetate, the third step in the pathway for the catabolism of TYROSINE. Deficiency in the enzyme causes ALKAPTONURIA, an autosomal recessive disorder, characterized by homogentisic aciduria, OCHRONOSIS and ARTHRITIS. This enzyme was formerly characterized as EC 1.13.1.5 and EC 1.99.2.5.
Preferred term Homogentisate 1,2-Dioxygenase
Entry term(s) 1,2-Dioxygenase, Homogentisate
Acid Oxidase, Homogentisic
Dioxygenase, Homogentisate
Homogentisate 1,2 Dioxygenase
Homogentisate Dioxygenase
Homogentisate Oxidase
Homogentisate Oxygenase
Homogentisic Acid Oxidase
Oxidase, Homogentisate
Oxidase, Homogentisic Acid
Oxygenase, Homogentisate



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