| Descriptor English: | Core Binding Factor alpha Subunits | ||||||
| Descriptor Spanish: |
Subunidades alfa del Factor de Unión al Sitio Principal
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| Descriptor Portuguese: | Subunidades alfa de Fatores de Ligação ao Core | ||||||
| Descriptor French: | Sous-unités alpha du facteur CBF | ||||||
| Entry term(s): |
Acute Myeloid Leukemia Proteins Core Binding Factor alpha Proteins PEBP2A Transcription Factors Polyomavirus Enhancer A Binding Protein 2 Polyomavirus Enhancer Binding Protein 2, Alpha Subunit Runt Domain Factor Runx Proteins Transcription Factors, PEBP2A |
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| Tree number(s): |
D12.776.930.155.200 |
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| RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D050657 | ||||||
| Scope note: | A family of transcription factors that bind to the cofactor CORE BINDING FACTOR BETA SUBUNIT to form core binding factor. Family members contain a highly conserved DNA-binding domain known as the runt domain. They can act as both activators and repressors of expression of GENES involved in CELL DIFFERENTIATION and CELL CYCLE progression. |
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| Allowable Qualifiers: |
AD administration & dosage AE adverse effects AG agonists AI antagonists & inhibitors AN analysis BI biosynthesis BL blood CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis DE drug effects DF deficiency EC economics GE genetics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PH physiology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UL ultrastructure UR urine |
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| Previous Indexing: |
DNA-Binding Proteins (1987-2005) Neoplasm Proteins (1997-2005) Transcription Factors (1987-2005) |
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| Public MeSH Note: | 2006; POLYOMAVIRUS ENHANCER A BINDING PROTEIN 2 was indexed under DNA-BINDING PROTEINS & TRANSCRIPTION FACTORS 1987-2005, & under NEOPLASM PROTEINS 1997-2005; RUNT DOMAIN FACTOR was indexed under DNA-BINDING PROTEINS & TRANSCRIPTION FACTORS 2000-2005, & under NEOPLASM PROTEINS 2000-2005 |
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| History Note: | 2006(1987) |
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| DeCS ID: | 51175 | ||||||
| Unique ID: | D050657 | ||||||
| Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||||
| Date Established: | 2006/01/01 | ||||||
| Date of Entry: | 2005/06/30 | ||||||
| Revision Date: | 2013/07/09 |
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CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins
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Core Binding Factor alpha Subunits
- Preferred
| Concept UI |
M0151835 |
| Scope note | A family of transcription factors that bind to the cofactor CORE BINDING FACTOR BETA SUBUNIT to form core binding factor. Family members contain a highly conserved DNA-binding domain known as the runt domain. They can act as both activators and repressors of expression of GENES involved in CELL DIFFERENTIATION and CELL CYCLE progression. |
| Preferred term | Core Binding Factor alpha Subunits |
| Entry term(s) |
Acute Myeloid Leukemia Proteins Core Binding Factor alpha Proteins PEBP2A Transcription Factors Polyomavirus Enhancer A Binding Protein 2 Polyomavirus Enhancer Binding Protein 2, Alpha Subunit Runt Domain Factor Runx Proteins Transcription Factors, PEBP2A |
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