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Descriptor English: Core Binding Factors
Descriptor Spanish: Factores de Unión al Sitio Principal
Descriptor factores de unión central
Entry term(s) CBF
CBFa
factores de unión al núcleo
Scope note: Factores de transcripción heterodiméricos que contienen subunidades alfa unidas al ADN (SUBUNIDADES ALFA DEL FACTOR DE UNIÓN AL SITIO PRINCIPAL) junto con subunidades beta sin capacidad de reconocimiento de secuencias de ADN, SUBUNIDAD BETA DEL FACTOR DE UNIÓN AL SITIO PRINCIPAL. El factor de unión al sitio principal regula la TRANSCRIPCIÓN de diversos GENES involucrados principalmente en la DIFERENCIACIÓN CELULAR y en la progresión del CICLO CELULAR.
Descriptor Portuguese: Fatores de Ligação ao Core
Descriptor French: Facteurs de transcription CBF
Entry term(s): Binding Factors, Core
Core Binding Factor
Core-Binding Factor
Factors, Core Binding
PEBP2 Transcription Factor
Polyomavirus Enhancer Binding Protein 2
Transcription Factor, PEBP2
Tree number(s): D12.776.930.155
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D050660
Scope note: Heterodimeric transcription factors containing a DNA-binding alpha subunits, (CORE BINDING FACTOR ALPHA SUBUNITS), along with a non-DNA-binding beta subunits, CORE BINDING FACTOR BETA SUBUNIT. Core Binding Factor regulates GENETIC TRANSCRIPTION of a variety of GENES involved primarily in CELL DIFFERENTIATION and CELL CYCLE progression.
Annotation: see SCR for organism-specific terms
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Previous Indexing: Neoplasm Proteins (1997-2005)
Transcription Factors (1997-2005)
Public MeSH Note: 2006; CORE-BINDING FACTOR was indexed under NEOPLASM PROTEINS & TRANSCRIPTION FACTORS 1997-2005
History Note: 2006(1997)
DeCS ID: 51174
Unique ID: D050660
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2006/01/01
Date of Entry: 2005/06/30
Revision Date: 2005/08/03
Core Binding Factors - Preferred
Concept UI M0211900
Scope note Heterodimeric transcription factors containing a DNA-binding alpha subunits, (CORE BINDING FACTOR ALPHA SUBUNITS), along with a non-DNA-binding beta subunits, CORE BINDING FACTOR BETA SUBUNIT. Core Binding Factor regulates GENETIC TRANSCRIPTION of a variety of GENES involved primarily in CELL DIFFERENTIATION and CELL CYCLE progression.
Preferred term Core Binding Factors
Entry term(s) Binding Factors, Core
Core Binding Factor
Core-Binding Factor
Factors, Core Binding
PEBP2 Transcription Factor
Polyomavirus Enhancer Binding Protein 2
Transcription Factor, PEBP2



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