| Descriptor English: | Core Binding Factor Alpha 2 Subunit | ||||||
| Descriptor Spanish: |
Subunidad alfa 2 del Factor de Unión al Sitio Principal
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| Descriptor Portuguese: | Subunidade alfa 2 de Fator de Ligação ao Core | ||||||
| Descriptor French: | Sous-unité alpha 2 du facteur CBF | ||||||
| Entry term(s): |
AML1A Protein AML1B Protein AML1C Protein AML1D Protein Acute Myeloid Leukemia 1 Protein Acute Myeloid Leukemia 1A Protein Acute Myeloid Leukemia 1B Protein Acute Myeloid Leukemia 1C Protein Acute Myeloid Leukemia 1D Protein Core Binding Factor Alpha 2 Protein Core-Binding Factor Alpha 2 Protein Pebp2a2 Protein Runt Related Transcription Factor 1 Runt-Related Transcription Factor 1 Runx1 Protein |
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| Tree number(s): |
D12.776.930.155.200.200 |
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| RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D050676 | ||||||
| Scope note: | A transcription factor that dimerizes with the cofactor CORE BINDING FACTOR BETA SUBUNIT to form core binding factor. It contains a highly conserved DNA-binding domain known as the runt domain. Runx1 is frequently mutated in human LEUKEMIAS. |
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| Allowable Qualifiers: |
AD administration & dosage AE adverse effects AG agonists AI antagonists & inhibitors AN analysis BI biosynthesis BL blood CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis DE drug effects DF deficiency EC economics GE genetics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PH physiology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UL ultrastructure UR urine |
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| Previous Indexing: |
DNA-Binding Proteins (1996-2005) Neoplasm Proteins (1993-1996) Proto-Oncogene Proteins (1996-2005) Transcription Factors (1996-2005) |
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| Public MeSH Note: | 2006; RUNX1 PROTEIN was indexed under DNA-BINDING PROTEINS 1996-2005, NEOPLASM PROTEINS 1993-1996, PROTO-ONCOGENE PROTEINS 1996-2005, & TRANSCRIPTION FACTORS 1996-2005 |
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| History Note: | 2006(1993) |
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| DeCS ID: | 51177 | ||||||
| Unique ID: | D050676 | ||||||
| Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||||
| Date Established: | 2006/01/01 | ||||||
| Date of Entry: | 2005/06/30 | ||||||
| Revision Date: | 2017/06/02 |
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CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins
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Core Binding Factor Alpha 2 Subunit
- Preferred
Acute Myeloid Leukemia 1D Protein
- Narrower
Acute Myeloid Leukemia 1C Protein
- Narrower
Acute Myeloid Leukemia 1B Protein
- Narrower
Acute Myeloid Leukemia 1A Protein
- Narrower
| Concept UI |
M0215816 |
| Scope note | A transcription factor that dimerizes with the cofactor CORE BINDING FACTOR BETA SUBUNIT to form core binding factor. It contains a highly conserved DNA-binding domain known as the runt domain. Runx1 is frequently mutated in human LEUKEMIAS. |
| Preferred term | Core Binding Factor Alpha 2 Subunit |
| Entry term(s) |
Acute Myeloid Leukemia 1 Protein Core Binding Factor Alpha 2 Protein Core-Binding Factor Alpha 2 Protein Pebp2a2 Protein Runt Related Transcription Factor 1 Runt-Related Transcription Factor 1 Runx1 Protein |
| Concept UI |
M0215813 |
| Preferred term | Acute Myeloid Leukemia 1D Protein |
| Entry term(s) |
AML1D Protein |
| Concept UI |
M0384755 |
| Preferred term | Acute Myeloid Leukemia 1C Protein |
| Entry term(s) |
AML1C Protein |
| Concept UI |
M0215812 |
| Preferred term | Acute Myeloid Leukemia 1B Protein |
| Entry term(s) |
AML1B Protein |
| Concept UI |
M0215811 |
| Preferred term | Acute Myeloid Leukemia 1A Protein |
| Entry term(s) |
AML1A Protein |
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