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Descriptor English: Interleukin 1 Receptor Antagonist Protein
Descriptor Spanish: Proteína Antagonista del Receptor de Interleucina 1
Descriptor proteína antagonista del receptor de interleucina 1
Scope note: Ligando que se une al RECEPTOR DE INTERLEUCINA-1 pero no llega a activarlo. Desempeña un papel inhibidor en la regulación de la INFLAMACIÓN y de la FIEBRE. Hay varias isoformas de la proteína debido al EMPALME ALTERNATIVO múltiple de su ARNm.
Descriptor Portuguese: Proteína Antagonista do Receptor de Interleucina 1
Descriptor French: Antagoniste du récepteur à l'interleukine-1
Entry term(s): Anakinra
Antril
Febrile Inhibitor, IL1
IL 1 Inhibitor, Urine
IL-1 Inhibitor, Urine
IL-1Ra
IL1 Febrile Inhibitor
IL1 Inhibitor, Urine-Derived
Interleukin 1 Inhibitor, Urine
Kineret
Urine Derived IL1 Inhibitor
Urine IL-1 Inhibitor
Urine-Derived IL1 Inhibitor
Tree number(s): D12.644.276.374.460
D12.776.467.374.460
D23.529.374.460
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D053590
Scope note: A ligand that binds to but fails to activate the INTERLEUKIN 1 RECEPTOR. It plays an inhibitory role in the regulation of INFLAMMATION and FEVER. Several isoforms of the protein exist due to multiple ALTERNATIVE SPLICING of its mRNA.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Pharm Action: Antirheumatic Agents
Public MeSH Note: 2007; INTERLEUKIN 1 RECEPTOR ANTAGONIST PROTEIN was indexed under SIALOGLYOPROTEINS 1990-2006, and under PROTEINS 1987-1989
History Note: 2007
DeCS ID: 52275
Unique ID: D053590
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2007/01/01
Date of Entry: 2006/07/05
Revision Date: 2016/07/01
Interleukin 1 Receptor Antagonist Protein - Preferred
Concept UI M0148648
Scope note A ligand that binds to but fails to activate the INTERLEUKIN 1 RECEPTOR. It plays an inhibitory role in the regulation of INFLAMMATION and FEVER. Several isoforms of the protein exist due to multiple ALTERNATIVE SPLICING of its mRNA.
Preferred term Interleukin 1 Receptor Antagonist Protein
Entry term(s) Febrile Inhibitor, IL1
IL 1 Inhibitor, Urine
IL-1 Inhibitor, Urine
IL-1Ra
IL1 Febrile Inhibitor
IL1 Inhibitor, Urine-Derived
Interleukin 1 Inhibitor, Urine
Urine Derived IL1 Inhibitor
Urine IL-1 Inhibitor
Urine-Derived IL1 Inhibitor
Antril - Narrower
Concept UI M0148640
Preferred term Antril
Kineret - Narrower
Concept UI M0475846
Preferred term Kineret
Anakinra - Narrower
Concept UI M0494869
Scope note A synthetic form of native human IL-1Ra that has an additional methionine residue at its amino terminus.
Preferred term Anakinra



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