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Descriptor in English: Tumor Necrosis Factors
Descriptor in Spanish: Factores de Necrosis Tumoral
Descriptor in Portuguese: Fatores de Necrose Tumoral
Descriptor in French: Facteurs de nécrose tumorale
Entry term(s): Necrosis Factors, Tumor
Receptor Ligands, TNF
TNF Receptor Ligands
Tumor Necrosis Factor Superfamily Ligands
Tree number(s): D12.644.276.374.750
D12.776.467.374.750
D23.529.374.750
Scope note: A family of proteins that were originally identified by their ability to cause NECROSIS of NEOPLASMS. Their necrotic effect on cells is mediated through TUMOR NECROSIS FACTOR RECEPTORS which induce APOPTOSIS.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AG agonists
AI antagonists & inhibitors
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UR urine
History Note: 2005
DeCS UI: 38737
Descriptor UI: D048069
Date Established: 2005/01/01
Date of Entry: 2004/07/07
Revision Date: 2015/06/23
Tumor Necrosis Factors - Preferred
Concept UI M0460559
Scope note A family of proteins that were originally identified by their ability to cause NECROSIS of NEOPLASMS. Their necrotic effect on cells is mediated through TUMOR NECROSIS FACTOR RECEPTORS which induce APOPTOSIS.
Preferred term Tumor Necrosis Factors
Entry term(s) Necrosis Factors, Tumor
Receptor Ligands, TNF
TNF Receptor Ligands
Tumor Necrosis Factor Superfamily Ligands - Related but not broader or narrower
Concept UI M0460560
Preferred term Tumor Necrosis Factor Superfamily Ligands



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