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Descriptor English: Cyclic Nucleotide Phosphodiesterases, Type 3
Descriptor Spanish: Fosfodiesterasas de Nucleótidos Cíclicos Tipo 3
Descriptor fosfodiesterasas de nucleótidos cíclicos tipo 3
Entry term(s) fosfodiesterasas de nucleótidos cíclicos de tipo 3
Scope note: Subfamilia de fosfodiesterasas de nucleótidos cíclicos que es inhibida por la unión del GMP CÍCLICO a un dominio alostérico que se encuentra en la enzima y a través de la fosforilación por parte de cinasas reguladoras, como la PROTEÍNA CINASA A y la PROTEÍNA CINASA B. Los dos miembros de esta familia se denomina de tipo 3A y de tipo 3B, y son el producto de genes distintos. Además, pueden producirse diversas variantes enzimáticas de cada subtipo debido a las múltiples alternativas de corte y empalme del ARNm.
Descriptor Portuguese: Nucleotídeo Cíclico Fosfodiesterase do Tipo 3
Descriptor French: Cyclic Nucleotide Phosphodiesterases, Type 3
Entry term(s): Cyclic Nucleotide Phosphodiesterase PDE3 Family
Cyclic Nucleotide Phosphodiesterases, Type 3A
Cyclic Nucleotide Phosphodiesterases, Type 3B
Phosphodiesterase 3A
Phosphodiesterase 3B
Phosphodiesterase III
Phosphodiesterase, cGMP-Inhibited
cGMP Inhibited Cyclic Nucleotide Phosphodiesterase
cGMP Inhibited Phosphodiesterase
cGMP-Inhibited Cyclic Nucleotide Phosphodiesterase
cGMP-Inhibited Phosphodiesterase
Tree number(s): D08.811.277.352.640.150.300
D12.776.476.008.300
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D054684
Scope note: A cyclic nucleotide phosphodiesterase subfamily that is inhibited by the binding of CYCLIC GMP to an allosteric domain found on the enzyme and through phosphorylation by regulatory kinases such as PROTEIN KINASE A and PROTEIN KINASE B. The two members of this family are referred to as type 3A, and type 3B, and are each product of a distinct gene. In addition multiple enzyme variants of each subtype can be produced due to multiple alternative mRNA splicing.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Entry Combination: antagonists & inhibitors:Phosphodiesterase 3 Inhibitors
Registry Number: EC 3.1.4.17
Public MeSH Note: 2008; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 3 was indexed under 3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE 1995-2007
History Note: 2008(1995)
DeCS ID: 52678
Unique ID: D054684
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2008/01/01
Date of Entry: 2007/07/09
Revision Date: 2015/11/23
Cyclic Nucleotide Phosphodiesterases, Type 3 - Preferred
Concept UI M0240466
Scope note A cyclic nucleotide phosphodiesterase subfamily that is inhibited by the binding of CYCLIC GMP to an allosteric domain found on the enzyme and through phosphorylation by regulatory kinases such as PROTEIN KINASE A and PROTEIN KINASE B. The two members of this family are referred to as type 3A, and type 3B, and are each product of a distinct gene. In addition multiple enzyme variants of each subtype can be produced due to multiple alternative mRNA splicing.
Preferred term Cyclic Nucleotide Phosphodiesterases, Type 3
Entry term(s) Cyclic Nucleotide Phosphodiesterase PDE3 Family
Phosphodiesterase III
Phosphodiesterase, cGMP-Inhibited
cGMP Inhibited Cyclic Nucleotide Phosphodiesterase
cGMP Inhibited Phosphodiesterase
cGMP-Inhibited Cyclic Nucleotide Phosphodiesterase
cGMP-Inhibited Phosphodiesterase
Cyclic Nucleotide Phosphodiesterases, Type 3B - Narrower
Concept UI M0354563
Preferred term Cyclic Nucleotide Phosphodiesterases, Type 3B
Entry term(s) Phosphodiesterase 3B
Cyclic Nucleotide Phosphodiesterases, Type 3A - Narrower
Concept UI M0367999
Preferred term Cyclic Nucleotide Phosphodiesterases, Type 3A
Entry term(s) Phosphodiesterase 3A



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