| Descriptor English: | Cyclic Nucleotide Phosphodiesterases, Type 6 | ||||||
| Descriptor Spanish: |
Fosfodiesterasas de Nucleótidos Cíclicos Tipo 6
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| Descriptor Portuguese: | Nucleotídeo Cíclico Fosfodiesterase do Tipo 6 | ||||||
| Descriptor French: | Cyclic Nucleotide Phosphodiesterases, Type 6 | ||||||
| Entry term(s): |
Cyclic Nucleotide Phosphodiesterases, Type 6, alpha Subunit Cyclic Nucleotide Phosphodiesterases, Type 6, beta Subunit Cyclic Nucleotide Phosphodiesterases, Type 6, delta Subunit Cyclic Nucleotide Phosphodiesterases, Type 6, gamma Subunit PDE6 Phosphodiesterases PDE6 alpha Subunit PDE6 beta Subunit PDE6 delta Subunit PDE6, alpha Subunit PDE6, beta Subunit PDE6, delta Subunit Phosphodiesterase 6 Phosphodiesterase 6, Retinal Phosphodiesterase Type 6 Phosphodiesterases, PDE6 Retinal Phosphodiesterase 6 Retinal Phosphodiesterase, alpha Subunit Retinal Phosphodiesterase, beta Subunit Retinal Phosphodiesterase, delta Subunit Rod cGMP Phosphodiesterase, beta Subunit alpha Subunit PDE6 alpha Subunit, PDE6 beta Subunit PDE6 beta Subunit, PDE6 cGMP PDE gamma Subunit cGMP Phosphodiesterase delta Subunit cGMP-PDE gamma Subunit delta Subunit PDE6 delta Subunit, PDE6 gamma Subunit, cGMP Phosphodiesterase gamma Subunit, cGMP-PDE |
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| Tree number(s): |
D08.811.277.352.640.150.600 D08.811.277.352.640.155.750 D12.776.476.008.600 D12.776.476.009.750 |
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| RDF Unique Identifier: | https://id.nlm.nih.gov/mesh/D054707 | ||||||
| Scope note: | A cyclic nucleotide phosphodiesterase subfamily that is highly specific for CYCLIC GMP. It is found predominantly in the outer segment PHOTORECEPTOR CELLS of the RETINA. It is comprised of two catalytic subunits, referred to as alpha and beta, that form a dimer. In addition two regulatory subunits, referred to as gamma and delta, modulate the activity and localization of the enzyme. |
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| Allowable Qualifiers: |
AD administration & dosage AE adverse effects AI antagonists & inhibitors AN analysis BI biosynthesis BL blood CF cerebrospinal fluid CH chemistry CL classification CS chemical synthesis DE drug effects DF deficiency EC economics GE genetics HI history IM immunology IP isolation & purification ME metabolism PD pharmacology PH physiology PK pharmacokinetics PO poisoning RE radiation effects SD supply & distribution ST standards TO toxicity TU therapeutic use UL ultrastructure UR urine |
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| Registry Number: | EC 3.1.4.35 | ||||||
| Public MeSH Note: | 2008; PHOSPHODIESTERASE 6 (now CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 6) was indexed under PHOSPHORIC ACID DIESTERASES 2001-2007; CGMP PHOSPHODIESTERASE DELTA SUBUNIT was indexed under 3,5,'-CYCLIC-GMP PHOSPHODIESTERASE 2004-2007 |
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| History Note: | 2008(2001) |
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| DeCS ID: | 52681 | ||||||
| Unique ID: | D054707 | ||||||
| Documents indexed in the Virtual Health Library (VHL): | Click here to access the VHL documents | ||||||
| Date Established: | 2008/01/01 | ||||||
| Date of Entry: | 2007/07/09 | ||||||
| Revision Date: | 2015/11/23 |
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CHEMICALS AND DRUGS
Enzymes and Coenzymes [D08]Enzymes and Coenzymes -
CHEMICALS AND DRUGS
Enzymes and Coenzymes [D08]Enzymes and Coenzymes -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins -
CHEMICALS AND DRUGS
Amino Acids, Peptides, and Proteins [D12]Amino Acids, Peptides, and Proteins
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Cyclic Nucleotide Phosphodiesterases, Type 6
- Preferred
Cyclic Nucleotide Phosphodiesterases, Type 6, beta Subunit
- Narrower
Cyclic Nucleotide Phosphodiesterases, Type 6, gamma Subunit
- Narrower
Cyclic Nucleotide Phosphodiesterases, Type 6, alpha Subunit
- Narrower
Cyclic Nucleotide Phosphodiesterases, Type 6, delta Subunit
- Narrower
| Concept UI |
M0379736 |
| Scope note | A cyclic nucleotide phosphodiesterase subfamily that is highly specific for CYCLIC GMP. It is found predominantly in the outer segment PHOTORECEPTOR CELLS of the RETINA. It is comprised of two catalytic subunits, referred to as alpha and beta, that form a dimer. In addition two regulatory subunits, referred to as gamma and delta, modulate the activity and localization of the enzyme. |
| Preferred term | Cyclic Nucleotide Phosphodiesterases, Type 6 |
| Entry term(s) |
PDE6 Phosphodiesterases Phosphodiesterase 6 Phosphodiesterase 6, Retinal Phosphodiesterase Type 6 Phosphodiesterases, PDE6 Retinal Phosphodiesterase 6 |
| Concept UI |
M0290860 |
| Preferred term | Cyclic Nucleotide Phosphodiesterases, Type 6, beta Subunit |
| Entry term(s) |
PDE6 beta Subunit PDE6, beta Subunit Retinal Phosphodiesterase, beta Subunit Rod cGMP Phosphodiesterase, beta Subunit beta Subunit PDE6 beta Subunit, PDE6 |
| Concept UI |
M0268874 |
| Preferred term | Cyclic Nucleotide Phosphodiesterases, Type 6, gamma Subunit |
| Entry term(s) |
cGMP PDE gamma Subunit cGMP-PDE gamma Subunit gamma Subunit, cGMP Phosphodiesterase gamma Subunit, cGMP-PDE |
| Concept UI |
M0507058 |
| Preferred term | Cyclic Nucleotide Phosphodiesterases, Type 6, alpha Subunit |
| Entry term(s) |
PDE6 alpha Subunit PDE6, alpha Subunit Retinal Phosphodiesterase, alpha Subunit alpha Subunit PDE6 alpha Subunit, PDE6 |
| Concept UI |
M0266688 |
| Preferred term | Cyclic Nucleotide Phosphodiesterases, Type 6, delta Subunit |
| Entry term(s) |
PDE6 delta Subunit PDE6, delta Subunit Retinal Phosphodiesterase, delta Subunit cGMP Phosphodiesterase delta Subunit delta Subunit PDE6 delta Subunit, PDE6 |
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