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Descriptor English: Cyclic Nucleotide Phosphodiesterases, Type 5
Descriptor Spanish: Fosfodiesterasas de Nucleótidos Cíclicos Tipo 5
Descriptor fosfodiesterasas de nucleótidos cíclicos tipo 5
Scope note: Subfamilia de fosfodiesterasas de nucleótidos cíclicos con gran especificidad por el GMP CÍCLICO. Se encuentra predominantemente en el tejido vascular y desempeña una función importante en la regulación de la contracción del MÚSCULO LISO VASCULAR.
Descriptor Portuguese: Nucleotídeo Cíclico Fosfodiesterase do Tipo 5
Descriptor French: Cyclic Nucleotide Phosphodiesterases, Type 5
Entry term(s): PDE5 Phosphodiesterases
Phosphodiesterase 5
Phosphodiesterase 5A
Phosphodiesterase 5A, cGMP Specific
Phosphodiesterase 5A, cGMP-Specific
Phosphodiesterase Type 5
Phosphodiesterase Type V
Phosphodiesterase V
Phosphodiesterase-5
Phosphodiesterases, PDE5
Type 5, Phosphodiesterase
Type V, Phosphodiesterase
cGMP-Binding, cGMP-Specific 3',5'-cyclic Nucleotide Phosphodiesterase
cGMP-Specific Phosphodiesterase 5A
Tree number(s): D08.811.277.352.640.150.500
D08.811.277.352.640.155.500
D12.776.476.008.500
D12.776.476.009.500
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D054706
Scope note: A cyclic nucleotide phosphodiesterase subfamily that is highly specific for CYCLIC GMP. It is found predominantly in vascular tissue and plays an important role in regulating VASCULAR SMOOTH MUSCLE contraction.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Entry Combination: antagonists & inhibitors:Phosphodiesterase 5 Inhibitors
Registry Number: EC 3.1.4.35
Public MeSH Note: 2008; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 5 was indexed under 3',5'-CYCLIC-GMP PHOSPHODIESTERASE 1998-2007
History Note: 2008(1998)
DeCS ID: 52680
Unique ID: D054706
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2008/01/01
Date of Entry: 2007/07/09
Revision Date: 2016/04/15
Cyclic Nucleotide Phosphodiesterases, Type 5 - Preferred
Concept UI M0295388
Scope note A cyclic nucleotide phosphodiesterase subfamily that is highly specific for CYCLIC GMP. It is found predominantly in vascular tissue and plays an important role in regulating VASCULAR SMOOTH MUSCLE contraction.
Preferred term Cyclic Nucleotide Phosphodiesterases, Type 5
Entry term(s) PDE5 Phosphodiesterases
Phosphodiesterase 5
Phosphodiesterase 5A
Phosphodiesterase 5A, cGMP Specific
Phosphodiesterase 5A, cGMP-Specific
Phosphodiesterase Type 5
Phosphodiesterase Type V
Phosphodiesterase V
Phosphodiesterase-5
Phosphodiesterases, PDE5
Type 5, Phosphodiesterase
Type V, Phosphodiesterase
cGMP-Binding, cGMP-Specific 3',5'-cyclic Nucleotide Phosphodiesterase
cGMP-Specific Phosphodiesterase 5A



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