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Descriptor English: Cyclic Nucleotide Phosphodiesterases, Type 4
Descriptor Spanish: Fosfodiesterasas de Nucleótidos Cíclicos Tipo 4
Descriptor fosfodiesterasas de nucleótidos cíclicos tipo 4
Entry term(s) fosfodiesterasas de nucleótidos cíclicos de tipo 4
Scope note: Subfamilia de fosfodiesterasas de nucleótidos cíclicos que se encuentra predominantemente en células inflamatorias y puede intervenir en la regulación de la INMUNIDAD CELULAR. La familia de enzimas incluye más de veinte variantes diferentes, fruto de las múltiples alternativas de corte y empalme del ARNm de al menos cuatro genes diferentes.
Descriptor Portuguese: Nucleotídeo Cíclico Fosfodiesterase do Tipo 4
Descriptor French: Cyclic Nucleotide Phosphodiesterases, Type 4
Entry term(s): Cyclic Nucleotide Phosphodiesterase PDE4 Family
Cyclic Nucleotide Phosphodiesterases, Type 4A
Cyclic Nucleotide Phosphodiesterases, Type 4A5
Cyclic Nucleotide Phosphodiesterases, Type 4B
Cyclic Nucleotide Phosphodiesterases, Type 4C
Cyclic Nucleotide Phosphodiesterases, Type 4D
Cyclic Nucleotide Phosphodiesterases, Type 4D3
PDE4 Phosphodiesterases
PDE4D3 Phosphodiesterase
Phosphodiesterase 4
Phosphodiesterase 4A
Phosphodiesterase 4A5, cAMP-Specific
Phosphodiesterase 4B
Phosphodiesterase 4C
Phosphodiesterase 4D
Phosphodiesterase IV
Phosphodiesterase, PDE4D3
Phosphodiesterase-4
Phosphodiesterases, PDE4
Type 4 Cyclic Nucleotide Phosphodiesterase
cAMP Specific Phosphodiesterase 4A5
cAMP-Specific Phosphodiesterase 4A5
Tree number(s): D08.811.277.352.640.150.400
D12.776.476.008.400
RDF Unique Identifier: https://id.nlm.nih.gov/mesh/D054703
Scope note: A cyclic nucleotide phosphodiesterase subfamily that is found predominantly in inflammatory cells and may play a role in the regulation of CELL-MEDIATED IMMUNITY. The enzyme family includes over twenty different variants that occur due to multiple ALTERNATIVE SPLICING of the mRNA of at least four different genes.
Allowable Qualifiers: AD administration & dosage
AE adverse effects
AN analysis
BI biosynthesis
BL blood
CF cerebrospinal fluid
CH chemistry
CL classification
CS chemical synthesis
DE drug effects
DF deficiency
EC economics
GE genetics
HI history
IM immunology
IP isolation & purification
ME metabolism
PD pharmacology
PH physiology
PK pharmacokinetics
PO poisoning
RE radiation effects
SD supply & distribution
ST standards
TO toxicity
TU therapeutic use
UL ultrastructure
UR urine
Entry Combination: antagonists & inhibitors:Phosphodiesterase 4 Inhibitors
Registry Number: EC 3.1.4.17
Public MeSH Note: 2008; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 4 was indexed under 3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE 1981-2007; CAMP-SPECIFIC PHOSPHODIESTERASE 4A5 was indexed under 3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE 2000-2007; PDE4D3 PHOSPHODIESTERASE was indexed under 3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE 1996-2007
History Note: 2008(1981)
DeCS ID: 52679
Unique ID: D054703
Documents indexed in the Virtual Health Library (VHL): Click here to access the VHL documents
Date Established: 2008/01/01
Date of Entry: 2007/07/09
Revision Date: 2015/11/23
Cyclic Nucleotide Phosphodiesterases, Type 4 - Preferred
Concept UI M0096215
Scope note A cyclic nucleotide phosphodiesterase subfamily that is found predominantly in inflammatory cells and may play a role in the regulation of CELL-MEDIATED IMMUNITY. The enzyme family includes over twenty different variants that occur due to multiple ALTERNATIVE SPLICING of the mRNA of at least four different genes.
Preferred term Cyclic Nucleotide Phosphodiesterases, Type 4
Entry term(s) Cyclic Nucleotide Phosphodiesterase PDE4 Family
PDE4 Phosphodiesterases
Phosphodiesterase 4
Phosphodiesterase IV
Phosphodiesterase-4
Phosphodiesterases, PDE4
Type 4 Cyclic Nucleotide Phosphodiesterase
Cyclic Nucleotide Phosphodiesterases, Type 4A5 - Narrower
Concept UI M0370964
Preferred term Cyclic Nucleotide Phosphodiesterases, Type 4A5
Entry term(s) Phosphodiesterase 4A5, cAMP-Specific
cAMP Specific Phosphodiesterase 4A5
cAMP-Specific Phosphodiesterase 4A5
Cyclic Nucleotide Phosphodiesterases, Type 4D3 - Narrower
Concept UI M0264075
Preferred term Cyclic Nucleotide Phosphodiesterases, Type 4D3
Entry term(s) PDE4D3 Phosphodiesterase
Phosphodiesterase, PDE4D3
Cyclic Nucleotide Phosphodiesterases, Type 4C - Narrower
Concept UI M0096213
Preferred term Cyclic Nucleotide Phosphodiesterases, Type 4C
Entry term(s) Phosphodiesterase 4C
Cyclic Nucleotide Phosphodiesterases, Type 4D - Narrower
Concept UI M0471971
Preferred term Cyclic Nucleotide Phosphodiesterases, Type 4D
Entry term(s) Phosphodiesterase 4D
Cyclic Nucleotide Phosphodiesterases, Type 4A - Narrower
Concept UI M0096212
Preferred term Cyclic Nucleotide Phosphodiesterases, Type 4A
Entry term(s) Phosphodiesterase 4A
Cyclic Nucleotide Phosphodiesterases, Type 4B - Narrower
Concept UI M0471970
Preferred term Cyclic Nucleotide Phosphodiesterases, Type 4B
Entry term(s) Phosphodiesterase 4B



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